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dc.contributor.authorGottfried, Carmem Juracy Silveirapt_BR
dc.contributor.authorBambini Júnior, Victoriopt_BR
dc.contributor.authorFrancis, Fionapt_BR
dc.contributor.authorRiesgo, Rudimar dos Santospt_BR
dc.contributor.authorSavino, Wilsonpt_BR
dc.date.accessioned2018-06-05T02:28:35Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1664-0640pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/179081pt_BR
dc.description.abstractAutism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production. Also, epidemiological studies have established a correlation of ASD with family history of autoimmune diseases; associations with major histocompatibility complex haplotypes and abnormal levels of immunological markers in the blood. Moreover, the use of animal models to study ASD is providing increasing information on the relationship between the immune system and the pathophysiology of ASD. Herein, we will discuss the accumulating literature for ASD, giving special attention to the relevant aspects of factors that may be related to the neuroimmune interface in the development of ASD, including changes in neuroplasticity.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in psychiatry. Lausanne. Vol. 6 (Sep. 2015), 121, [16 p.]pt_BR
dc.rightsOpen Accessen
dc.subjectAutismen
dc.subjectTranstorno do espectro autistapt_BR
dc.subjectNeuroimmune interactionsen
dc.subjectEnvironmental risk factorsen
dc.subjectRodent modelsen
dc.subjectValproic aciden
dc.titleThe impact of neuroimmune alterations in autism spectrum disorderpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001068240pt_BR
dc.type.originEstrangeiropt_BR


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