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dc.contributor.authorBischoff, Adrianne Rahdept_BR
dc.contributor.authorDornelles, Alícia Dornelespt_BR
dc.contributor.authorCarvalho, Clarissa Gutierrezpt_BR
dc.date.accessioned2017-06-28T02:29:23Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn2296-6870pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/163558pt_BR
dc.description.abstractBackground/Aims: Hypernatremic dehydration in term neonates is associated with inadequate fluid intake, usually related to insufficient lactation. The use of hypotonic fluids is appropriate to dilute serum sodium (SNa), but cerebral edema may develop when it happens abruptly. Our objective was to clarify how to correct hypernatremic dehydration properly. Methods: The following databases were searched, limited to studies published until January 31st, 2016: Clinical Trials, MEDLINE/PubMed, EMBASE, LILACS, and the Cochrane Library. We included open-label trials, nonrandomized controlled trials, or prospective and retrospective case series evaluating relevant outcomes. Information regarding the way of administering the treatment, type of fluid used, rates of complications and outcomes, as well as the rate of SNa reduction were collected. Results: Searches yielded 771 articles: 64 had the full text reviewed and 9 were included. No randomized clinical trials or systematic reviews focusing on treatment of hypernatremic dehydration and its outcomes were found. We found a scarcity of high quality studies and great methodology heterogeneity. Conclusions: More severe hypernatremia is at greater risk of causing severe adverse effects of treatment. There is no consensus about the optimal rate of SNa drop in this population, but a slower correction appears to be safer. Questions as when parenteral fluids are indicated remain unanswered.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBiomedicine hub. Basel. Vol. 2, no. 1 (Jan./Apr. 2017), 454980, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectHipernatremiapt_BR
dc.subjectHypernatremic dehydrationen
dc.subjectHypernatremia treatmenten
dc.subjectEdema encefálicopt_BR
dc.subjectTerm neonatesen
dc.subjectRecém-nascidopt_BR
dc.subjectSerum sodiumen
dc.subjectCerebral edemaen
dc.subjectBreastfeedingen
dc.titleTreatment of hypernatremia in breastfeeding neonates : a systematic reviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001017657pt_BR
dc.type.originEstrangeiropt_BR


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