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dc.contributor.authorAmorin, Brunapt_BR
dc.contributor.authorAlegretti, Ana Paulapt_BR
dc.contributor.authorValim, Vanessa de Souzapt_BR
dc.contributor.authorSilva, Annelise Martins Pezzi dapt_BR
dc.contributor.authorSilva, Maria Aparecida Lima dapt_BR
dc.contributor.authorSehn, Filipept_BR
dc.contributor.authorSilla, Lucia Mariano da Rochapt_BR
dc.date.accessioned2016-11-26T02:19:21Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn2325-7776pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/149887pt_BR
dc.description.abstractMesenchymal stem cells (MSC) are considered non-hematopoietic multipotent stem cells with self-renewal properties and the ability to differentiate into a variety of mesenchymal tissues. Optimal conditions for the culture of these cells have been the subject of investigation for several years. In particular, ideal oxygen tension levels have not been estab-lished in the literature. In physiological environments, oxygen tension may vary from 12% in peripheral blood to 1% in the deep zone of cartilage regions. In any case, oxygen tension is considerably lower in vivo when compared with the normal atmosphere of standard cell culture conditions (21%). The objective of this study was to review the literature available on MSC characteristics (cell cycle, survival, proliferation, differentiation, morphology, immunophenotype, cytogenetics) when cultured under hypoxic conditions. Our focus on optimal culture conditions is justified by the key role currently played by these cells in regenerative medicine.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofCellBio. Delaware. Vol. 2, no. 1 (Mar. 2013), p. 11-19pt_BR
dc.rightsOpen Accessen
dc.subjectMesenchymal stem cellsen
dc.subjectCélulas-troncopt_BR
dc.subjectHipóxiapt_BR
dc.subjectCultureen
dc.subjectHypoxiaen
dc.titleCharacteristics of mesenchymal stem cells under hypoxiapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000877531pt_BR
dc.type.originEstrangeiropt_BR


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