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dc.contributor.authorRodrigues, Felipe Valle Fortespt_BR
dc.contributor.authorPezzi, Annelisept_BR
dc.contributor.authorLaureano, Álvaro Macedopt_BR
dc.contributor.authorValim, Vanessa de Souzapt_BR
dc.contributor.authorZambonato, Bruna Pochmannpt_BR
dc.contributor.authorDahmer, Alicept_BR
dc.contributor.authorBaggio, Letíciapt_BR
dc.contributor.authorSehn, Filipept_BR
dc.contributor.authorWilke, Ianaê Indiarapt_BR
dc.contributor.authorSilva, Maria Aparecida Lima dapt_BR
dc.contributor.authorAmorin, Brunapt_BR
dc.date.accessioned2016-11-19T02:16:45Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.issn2325-7776pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/149743pt_BR
dc.description.abstractBackground: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC are present in several adult tissues which milieu may influence MSC behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state of activation. Methods: To address the influence of the MSC source on its characteristics, we studied a xenofree, platelet lysate supplemented MSC from dental pulp, adipose tissue and bone marrow, co-cultured with isolated T cells and PBMC subset, and studied the effect of culture animal or human supplements immunomodulatory effect. Results: All three sources were efficient in inhibiting T cells. Among all MSC sources, as also described by others, adipose MSC was capable to significantly induce Treg phenotype and decrease T CD8+. Furthermore, comparing fetal bovine serum and platelet lysate, results demonstrate that platelet lysate alone is capable to induce immunomodulatory phenotype. Additional studies have to be made to elucidate the PL immunomodulatory effect.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofCellBio. Delaware. Vol. 5 (2016), p. 15-25pt_BR
dc.rightsOpen Accessen
dc.subjectMesenchymal stromal cellsen
dc.subjectAdipócitospt_BR
dc.subjectDoenças do sistema imunept_BR
dc.subjectDental pulpen
dc.subjectCélulas mesenquimais estromaispt_BR
dc.subjectAdipose tissueen
dc.subjectBone marrowen
dc.subjectT cells immunomodulatory effecten
dc.titleAdipocyte derived mesenchymal stromal cell and platelet lysate : ideal cell and supplement for the treatment of immune-inflammatory diseases?pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001004238pt_BR
dc.type.originEstrangeiropt_BR


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