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dc.contributor.authorBaierle, Maríliapt_BR
dc.contributor.authorCharão, Mariele Feifferpt_BR
dc.contributor.authorGöethel, Gabrielapt_BR
dc.contributor.authorBarth, Anelisept_BR
dc.contributor.authorFracasso, Rafaelpt_BR
dc.contributor.authorBubols, Guilherme Borgespt_BR
dc.contributor.authorSauer, Elisapt_BR
dc.contributor.authorCampanharo, Sarah Chagaspt_BR
dc.contributor.authorRocha, Rafael Christian Chávezpt_BR
dc.contributor.authorSaint'Pierre, Tatiana Dillenburgpt_BR
dc.contributor.authorBordignon, Suelenpt_BR
dc.contributor.authorZibetti, Murilo Ricardopt_BR
dc.contributor.authorTrentini, Clarissa Marcelipt_BR
dc.contributor.authorÁvila, Daiana Silva dept_BR
dc.contributor.authorGioda, Adrianapt_BR
dc.contributor.authorGarcia, Solange Cristinapt_BR
dc.date.accessioned2016-05-04T02:07:10Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1660-4601pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/140110pt_BR
dc.description.abstractAging is often accompanied by cognitive impairments and influenced by oxidative status and chemical imbalances. Thus, this study was conducted to examinewhether age-related cognitive deficit is associated with oxidative damage, especially with inhibition of the enzyme delta-aminolevulinate dehydratase (ALA-D), as well as to verify the influence of some metals in the enzyme activity and cognitive performance. Blood ALA-D activity, essential (Fe, Zn, Cu, Se) and non-essential metals (Pb, Cd, Hg, As, Cr, Ni, V) were measured in 50 elderly and 20 healthy young subjects. Cognitive function was assessed by tests from Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) battery and other. The elderly group presented decreased ALA-D activity compared to the young group. The index of ALA-D reactivation was similar to both study groups, but negatively associated with metals. The mean levels of essential metals were within the reference values, while the most toxic metals were above them in both groups. Cognitive function impairments were observed in elderly group and were associated with decreased ALA-D activity, with lower levels of Se and higher levels of toxic metals (Hg and V). Results suggest that the reduced ALA-D activity in elderly can be an additional factor involved in cognitive decline, since its inhibition throughout life could lead to accumulation of the neurotoxic compound ALA. Toxic metals were found to contribute to cognitive decline and also to influence ALA-D reactivation.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational Journal of Environmental Research and Public Health. Beijing. Vol. 11, no.10 (2014), p. 10851-10867pt_BR
dc.rightsOpen Accessen
dc.subjectALA-Den
dc.subjectFarmáciapt_BR
dc.subjectCognitive declineen
dc.subjectCognitive assessmenten
dc.subjectToxic metalsen
dc.subjectEssential metalsen
dc.titleAre delta-aminolevulinate dehydratase inhibition and metal concentrations additional factors for the age-related cognitive decline?pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000978148pt_BR
dc.type.originEstrangeiropt_BR


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