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dc.contributor.authorJesus, Luciano Henrique dept_BR
dc.contributor.authorHildebrand, Laura de Campospt_BR
dc.contributor.authorMartins, Manoela Dominguespt_BR
dc.contributor.authorRosa, Francinne Miranda dapt_BR
dc.contributor.authorDanilevicz, Chris Krebspt_BR
dc.contributor.authorSant'Ana Filho, Manoelpt_BR
dc.date.accessioned2015-11-25T02:39:53Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1178-7015pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/130223pt_BR
dc.description.abstractPolymethylmethacrylate (PMMA) has been widely used in the correction of wrinkles because of its long-lasting cosmetic improvements. However, side effects and complications may occur, and its clinical appearance on the oral mucosa can be similar to that of inflammatory or neoplastic disease. The aim of this research was to compare the clinical and histopathologic responses to PMMA injected by two different methods. Twenty-two rats received an injection of PMMA using the tunneling technique (gold standard), with subcutaneous deposition of the filler in the face, or a variation of the technique with transcutaneous submucosal deposition of the filler in the cheek. The tissue reaction was analyzed clinically every 24 hours during the first week, then once a week for the following 3 months. Histologic evaluation was based on the local inflammatory response to the filler. No clinical changes were observed during the initial evaluation period (0–14 days). After 14 days, only the submucosal group showed extra-oral enlargement (n=4, 18.2%). Histopathologic analysis revealed nodule formation in four animals (18.2%) in the submucosal group, with no nodules observed in the subcutaneous group. The data obtained in this study demonstrate that the technique used to deliver the filler may influence the risk of adverse reactions.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofClinical, cosmetic and investigational dermatology. Auckland, NZ. Vol. 8 (Aug. 2015), p. 431-436pt_BR
dc.rightsOpen Accessen
dc.subjectPolimetil metacrilatopt_BR
dc.subjectDermal filleren
dc.subjectEfeitos adversospt_BR
dc.subjectPolymethylmethacrylateen
dc.subjectMateriais odontologicospt_BR
dc.subjectAdverse reactionsen
dc.titleLocation of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000974170pt_BR
dc.type.originEstrangeiropt_BR


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