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dc.contributor.authorAdad, Lucia Maria de Mirandapt_BR
dc.contributor.authorAndrade, Heloisa Helena Rodrigues dept_BR
dc.contributor.authorKvitko, Katiapt_BR
dc.contributor.authorLehmann, Mauríciopt_BR
dc.contributor.authorCavalcante, Ana Amélia de C. Melopt_BR
dc.contributor.authorDihl, Rafael Rodriguespt_BR
dc.date.accessioned2015-11-10T02:41:31Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/129440pt_BR
dc.description.abstractFarm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micronucleus assay, hematological and lipid parameters, butyrylcholinesterase (BChE) activity and genetic polymorphisms of enzymes involved in the metabolism of pesticides, such as PON1, as well as of the DNA repair system (OGG1, XRCC1 and XRCC4). Two groups of farm workers exposed to different types of pesticides were evaluated and compared to matched non-exposed control groups. A significant increase was observed in the frequencies of micronuclei, kariorrhexis, karyolysis and binucleated cells in the exposed groups (n = 100) compared to controls (n = 100). No differences were detected regarding the hematological parameters, lipid profile and BChE activity. No significant difference was observed either regarding DNA damage or nuclear fragmentation when specific metabolizing and DNA repair genotypes were investigated in the exposed groups.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 308-315pt_BR
dc.rightsOpen Accessen
dc.subjectHuman monitoringen
dc.subjectTeste de micronúcleospt_BR
dc.subjectBuccal micronucleus testen
dc.subjectReparo do DNApt_BR
dc.subjectPesticidapt_BR
dc.subjectPesticidesen
dc.subjectPON 1en
dc.subjectDNA repair genesen
dc.titleOccupational exposure of workers to pesticides : toxicogenetics and susceptibility gene polymorphismspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000974451pt_BR
dc.type.originNacionalpt_BR


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