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dc.contributor.authorMigliavacca, Raphaella de Oliveirapt_BR
dc.contributor.authorPiltcher, Otavio Bejzmanpt_BR
dc.contributor.authorKliemann, Lucia Mariapt_BR
dc.contributor.authorCerski, Marcelle Reesinkpt_BR
dc.contributor.authorMeyer, Fabiola Schonspt_BR
dc.contributor.authorOppermann, Paula de Oliveirapt_BR
dc.contributor.authorMachado Filho, Geraldopt_BR
dc.contributor.authorKang, Suzie Hyeonapt_BR
dc.contributor.authorCosta, Sady Selaimen dapt_BR
dc.date.accessioned2015-06-26T02:00:04Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn0102-8650pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/118228pt_BR
dc.description.abstractPURPOSE: Evaluate and compare two different experimental techniques of maxillary sinus ostium occlusion using N-butyl cyanoacrylate in developing chronic histological findings without the inoculation of pathogenic bacteria among rabbits. METHODS: In a randomized study, sixteen New Zealand rabbits were assigned for occlusion of the right maxillary sinus through a transmaxillary approach or through the roof of the nasal cavity. The contralateral sinus served as a control. After 12 weeks, the animals were sacrificed for blinded histopathological analysis of the maxillary sinus mucosa. RESULTS: Histopathological changes consistent with CRS were found in eight (100%) of the maxillary sinuses approached transmaxillary and three of those through the roof of the nasal cavity (37.5%), p 0.008 and 0.250, respectively, comparing with the control side. Chronic mucosal changes were significantly better induced using the transmaxillary approach (p 0.026). CONCLUSION: It is possible to induce a model of chronic sinusitis among rabbits with transmaxillary sinus occlusion without bacterial inoculation. This model can be replicated for future cellular studies.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofActa cirúrgica brasileira. São Paulo. Vol. 29, n. 5 (2014), p. 313-319pt_BR
dc.rightsOpen Accessen
dc.subjectSinusitept_BR
dc.subjectModelos animais de doençaspt_BR
dc.subjectModelos animaispt_BR
dc.subjectSinusite maxilarpt_BR
dc.subjectCoelhospt_BR
dc.titleAn experimental model of chronic rhinosinusitis in rabbits without bacterial inoculationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000965332pt_BR
dc.type.originNacionalpt_BR


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