Glucose and triglyceride excursions following a standardized meal in individuals with diabetes : ELSA-Brasil study
dc.contributor.author | Riboldi, Bárbara Pelicioli | pt_BR |
dc.contributor.author | Luft, Vivian Cristine | pt_BR |
dc.contributor.author | Castilhos, Cristina Dickie de | pt_BR |
dc.contributor.author | Cardoso, Letícia de Oliveira | pt_BR |
dc.contributor.author | Schmidt, Maria Inês | pt_BR |
dc.contributor.author | Barreto, Sandhi Maria | pt_BR |
dc.contributor.author | Diniz, Maria de Fátima Haueisen Sander | pt_BR |
dc.contributor.author | Matos, Sheila Maria Alvim de | pt_BR |
dc.contributor.author | Duncan, Bruce Bartholow | pt_BR |
dc.date.accessioned | 2015-03-05T01:57:58Z | pt_BR |
dc.date.issued | 2015 | pt_BR |
dc.identifier.issn | 1475-2840 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/111680 | pt_BR |
dc.description.abstract | Objective: To assess glucose and triglyceride excursions 2 hours after the ingestion of a standardized meal and their associations with clinical characteristics and cardiovascular complications in individuals with diabetes. Research design and methods: Blood samples of 898 subjects with diabetes were collected at fasting and 2 hours after a meal containing 455 kcal, 14 g of saturated fat and 47 g of carbohydrates. Self-reported morbidity, socio-demographic characteristics and clinical measures were obtained by interview and exams performed at the baseline visit of the ELSA-Brasil cohort study. Results: Median (interquartile range, IQR) for fasting glucose was 150.5 (123–198) mg/dL and for fasting triglycerides 140 (103–199) mg/dL. The median excursion for glucose was 45 (15–76) mg/dL and for triglycerides 26 (11–45) mg/dL. In multiple linear regression, a greater glucose excursion was associated with higher glycated hemoglobin (10.7, 95% CI 9.1–12.3 mg/dL), duration of diabetes (4.5; 2.6–6.4 mg/dL, per 5 year increase), insulin use (44.4; 31.7–57.1 mg/dL), and age (6.1; 2.5–9.6 mg/dL, per 10 year increase); and with lower body mass index (−5.6; −8.4– -2.8 mg/dL, per 5 kg/m2 increase). In adjusted logistic regression models, a greater glucose excursion was marginally associated with the presence of cardiovascular comorbidities (coronary heart disease, myocardial infarction and angina) in those with obesity. Conclusions: A greater postprandial glycemic response to a small meal was positively associated with indicators of a decreased capacity for insulin secretion and negatively associated with obesity. No pattern of response was observed with a greater postprandial triglyceride excursion. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Cardiovascular diabetology. London. Vol. 14 (Feb. 2015), p. 21, 9 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Diabetes mellitus | pt_BR |
dc.subject | Doenças cardiovasculares | pt_BR |
dc.subject | Carboidratos da dieta | pt_BR |
dc.subject | Triglicerídeos | pt_BR |
dc.subject | Glicemia | pt_BR |
dc.subject | Obesidade | pt_BR |
dc.subject | Epidemiologia | pt_BR |
dc.title | Glucose and triglyceride excursions following a standardized meal in individuals with diabetes : ELSA-Brasil study | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000953259 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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