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dc.contributor.authorWajner, Simone Magagninpt_BR
dc.contributor.authorMaia, Ana Luiza Silvapt_BR
dc.date.accessioned2015-03-04T01:57:54Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1664-2392pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/111607pt_BR
dc.description.abstractThe non-thyroidal illness syndrome (NTIS) refers to changes in serum thyroid hormone levels observed in critically ill patients in the absence of hypothalamic–pituitary–thyroid primary dysfunction. Affected individuals have low T3, elevated rT3, and inappropriately normal TSH levels. The pathophysiological mechanisms are poorly understood but the acute and chronic changes in pituitary–thyroid function are probably the consequence of the action of multi- ple factors. The early phase seems to reflect changes occurring primarily in the peripheral thyroid hormone metabolism, best seen in humans since 80–90% of the circulating T3 are derived from the pro-hormone T4. The conversion of T4 to T3 is catalyzed by type 1 (D1) and type 2 (D2) deiodinases via outer-ring deiodination. In contrast, type 3 deiodinase (D3) catalyzes the inactivation of both T4 and T3. Over the last decades, several studies have attempted to elucidate the mechanisms underlying the changes on circulating thyroid hor- mones in NTIS. Increased inflammatory cytokines, which occurs in response to virtually any illness, has long been speculated to play a role in derangements of deiodinase expres- sion. On the other hand, oxidative stress due to augmented reactive oxygen species (ROS) generation is characteristic of many diseases that are associated with NTIS. Changes in the intracellular redox state may disrupt deiodinase function by independent mechanisms, which might include depletion of the as yet unidentified endogenous thiol cofactor. Here we aim to present an updated picture of the advances in understanding the mechanisms that result in the fall of thyroid hormone levels in the acute phase of NTIS.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in endocrinology. Lausanne. Vol. 3 (Jan. 26, 2012), 8, 7 p.pt_BR
dc.rightsOpen Accessen
dc.subjectSíndromes do eutireóideo doentept_BR
dc.subjectNon-thyroidal illness syndromeen
dc.subjectOxidative stressen
dc.subjectEstresse oxidativopt_BR
dc.subjectHormônios tireóideospt_BR
dc.subjectDeiodinasesen
dc.subjectThyroid hormoneen
dc.subjectIodeto peroxidasept_BR
dc.titleNew insights toward the acute non-thyroidal illness syndromept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000941913pt_BR
dc.type.originEstrangeiropt_BR


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