High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice
dc.contributor.author | Müller, Alexandre Pastoris | pt_BR |
dc.contributor.author | Dietrich, Marcelo de Oliveira | pt_BR |
dc.contributor.author | Assis, Adriano Martimbianco de | pt_BR |
dc.contributor.author | Souza, Diogo Onofre Gomes de | pt_BR |
dc.contributor.author | Portela, Luis Valmor Cruz | pt_BR |
dc.date.accessioned | 2015-02-19T02:16:41Z | pt_BR |
dc.date.issued | 2013 | pt_BR |
dc.identifier.issn | 2046-2395 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/110186 | pt_BR |
dc.description.abstract | Background: Obesity is a health problem that is reaching epidemic proportions worldwide. We investigated the effects of a life-long high saturated fat and low carbohydrate (HF) diet on the body mass, glucose tolerance, cognitive performance and lifespan of mice. Findings: C57BL/6J mice were fed with a HF diet (60% kcal/fat) or control diets (15% kcal/fat) for 27 months. One-half of the mice on the HF diet developed obesity (diet-induced obese (DIO) mice), whereas the remaining mice were diet resistant (DR). At 8 months of age, both DIO and DR groups had increased hyperglycemic response during a glucose tolerance test, which was normalized in 16-month-old mice. At this latter time point, all groups presented similar performance in cognitive tests (Morris water maze and inhibitory avoidance). The survival curves of the HF and control diet groups started to diverge at 15 months of age and, after 27 months, the survival rate of mice in the DIO and DR groups was 40%, whereas in the control diet group it was 75%. Conclusions: AHFdiet decreased the survival of mice independent of bodyweight. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Longevity and healthspan. London. Vol. 2, no. 1 (Jun. 2013), p. 10 [5 p.] | pt_BR |
dc.rights | Open Access | en |
dc.subject | Obesidade | pt_BR |
dc.subject | Obesity | en |
dc.subject | Gorduras na dieta | pt_BR |
dc.subject | Glucose tolerance | en |
dc.subject | High-fat diet | en |
dc.subject | Memória | pt_BR |
dc.subject | Glucose | pt_BR |
dc.subject | Memory | en |
dc.subject | Survival | en |
dc.title | High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000935437 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
Files in this item
This item is licensed under a Creative Commons License
![](/themes/Mirage2Novo//images/lume/cc.png)
-
Journal Articles (39541)Biological Sciences (3081)