Hepatic oxidative stress in an animal model of sleep apnoea : effects of different duration of exposure
dc.contributor.author | Rosa, Darlan Pase da | pt_BR |
dc.contributor.author | Martinez, Denis | pt_BR |
dc.contributor.author | Picada, Jaqueline Nascimento | pt_BR |
dc.contributor.author | Semedo, Juliane Garcia | pt_BR |
dc.contributor.author | Marroni, Norma Anair Possa | pt_BR |
dc.date.accessioned | 2015-02-11T02:18:05Z | pt_BR |
dc.date.issued | 2011 | pt_BR |
dc.identifier.issn | 1476-5926 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/109959 | pt_BR |
dc.description.abstract | Background: Repeated apnoea events cause intermittent hypoxia (IH), which alters the function of various systems and produces free radicals and oxidative stress. Methods: We investigated hepatic oxidative stress in adult mice subjected to intermittent hypoxia, simulating sleep apnoea. Three groups were submitted to 21 days of IH (IH-21), 35 days of IH (IH-35), or 35 days of sham IH. We assessed the oxidative damage to lipids by TBARS and to DNA by comet assay; hepatic tissue inflammation was assessed in HE-stained slides. Antioxidants were gauged by catalase, superoxide dismutase, glutathione peroxidase activity and by total glutathione. Results: After IH-21, no significant change was observed in hepatic oxidative stress. After IH-35, significant oxidative stress, lipid peroxidation, DNA damage and reduction of endogenous antioxidants were detected. Conclusions: In an animal model of sleep apnoea, intermittent hypoxia causes liver damage due to oxidative stress after 35 days, but not after 21 days. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Comparative hepatology. London. Vol. 10 (Jul. 2011), [7] p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Estresse oxidativo | pt_BR |
dc.subject | Modelos animais de doenças | pt_BR |
dc.subject | Hipóxia | pt_BR |
dc.subject | Apneia obstrutiva do sono | pt_BR |
dc.title | Hepatic oxidative stress in an animal model of sleep apnoea : effects of different duration of exposure | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000786705 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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