Chronic inflammation role in the obesity-diabetes association : a case-cohort study
dc.contributor.author | Luft, Vivian Cristine | pt_BR |
dc.contributor.author | Schmidt, Maria Inês | pt_BR |
dc.contributor.author | Pankow, James S. | pt_BR |
dc.contributor.author | Couper, David J. | pt_BR |
dc.contributor.author | Ballantyne, Christie M. | pt_BR |
dc.contributor.author | Young, J. Hunter | pt_BR |
dc.contributor.author | Duncan, Bruce Bartholow | pt_BR |
dc.date.accessioned | 2014-10-04T02:14:15Z | pt_BR |
dc.date.issued | 2013 | pt_BR |
dc.identifier.issn | 1758-5996 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/104194 | pt_BR |
dc.description.abstract | Background: Chronic inflammation is related to both obesity and diabetes. Our aim was to investigate to what extent this inflammation contributes to the association between obesity and diabetes. Methods: Using a case-cohort design, we followed 567 middle-aged individuals who developed diabetes and 554 who did not over 9 years within the ARIC Study. Weighted Cox proportional hazards analyses permitted statistical inference to the entire cohort. Results: Obese individuals (BMI≥30 kg/m²), compared to those with BMI<25 kg/m², presented a large increased risk of developing diabetes (HR[obesity]=6.4, 95%CI 4.5–9.2), as did those in the highest (compared to the lowest) quartile of waist circumference (HR[waist]=8.3, 95%CI 5.6–12.3), in analyses adjusted for age, gender, ethnicity, study center, and parental history of diabetes. Notably, further adjustment for adiponectin and inflammation markers halved the magnitude of these associations (HR[obesity]=3.2, 95%CI 2.1–4.7; and HR[waist]=4.2, 95%CI 2.8–6.5). In similar modeling, attenuation obtained by adding fasting insulin, instead of these markers, was only slightly more pronounced HR[obesity]=2.7, 95%CI 1.7–4.1; and HR[waist]=3.6, 95%CI 2.3–5.8). Conclusions: The marked decrease in the obesity-diabetes association after taking into account inflammation markers and adipokines indicates their major role in the pathways leading to adult onset of diabetes in obese individuals. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Diabetology and metabolic syndrome. [London]. Vol. 5 (2013), 31, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Epidemiologic studies | en |
dc.subject | Diabetes mellitus | pt_BR |
dc.subject | Obesidade | pt_BR |
dc.subject | Obesity | en |
dc.subject | Inflammation | en |
dc.subject | Inflamação | pt_BR |
dc.subject | Adipocinas | pt_BR |
dc.subject | Adipokines | en |
dc.subject | Estudos epidemiológicos | pt_BR |
dc.subject | Humans | en |
dc.title | Chronic inflammation role in the obesity-diabetes association : a case-cohort study | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000929918 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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