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dc.contributor.authorKülkamp-Guerreiro, Irene Clemespt_BR
dc.contributor.authorPaese, Karinapt_BR
dc.contributor.authorGuterres, Silvia Stanisçuaskipt_BR
dc.contributor.authorPohlmann, Adriana Raffinpt_BR
dc.date.accessioned2013-07-02T01:43:20Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/72881pt_BR
dc.description.abstractThis work reports the development of polymeric nanocapsules containing lipoic acid prepared by interfacial deposition of poli(ε-caprolactona). The suspensions showed acid pH and encapsulation efficiencies from 77 to 90%. Zeta potential values were from -7.42 to -5.43 mV and particle sizes were lower than 340 nm with polidispersion lower than 0.3. The stability of nanocapsules within 28 days was evaluated in terms of pH, lipoic acid content, diameter, size distribution, zeta potential and measurements of relative light backscattering. The stability of formulations containing free lipoic acid was also evaluated. Nanoencapsulation drastically improved the physico-chemical stability of lipoic acid.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoporpt_BR
dc.relation.ispartofQuímica nova. São Paulo. Vol. 32, n. 8 (2009), p. 2078-2084pt_BR
dc.rightsOpen Accessen
dc.subjectNanocapsulesen
dc.subjectNanocápsulaspt_BR
dc.subjectÁcido lipóicopt_BR
dc.subjectLipoic aciden
dc.subjectStabilizationen
dc.titleEstabilização do ácido lipoico via encapsulação em nanocápsulas poliméricas planejadas para aplicação cutâneapt_BR
dc.title.alternativeStabilization of lipoic acid by encapsulation in polymeric nanocapsules designed for cutaneous administration en
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000728135pt_BR
dc.type.originNacionalpt_BR


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