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dc.contributor.advisorLucion, Aldo Boltenpt_BR
dc.contributor.authorNunes, Wagner de Paulapt_BR
dc.date.accessioned2013-06-13T01:45:27Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/72411pt_BR
dc.description.abstractThe Neonatal Handling (NH) model presents a “blunted” corticosterone response to stress as well as an enhancement in contextual fear tasks. So the aim of this work was to examine a possible relationship between diminished imunosuppression over Interleukin 1 beta (IL-1) hippocampal levels and enhancement in aversive learning. To achieve that, we subjected male handled Wistar rats 30-35 and 90 days old to an inhibitory avoidance task, comparing the avoidance scores with respective hippocampal IL-1 levels at different time points. We found that handled adult animals learned the aversive task concomitantly with higher levels of hippocampal interleukin 1 beta 2h after footshock, while control animals showed diminished aversive learning and lower IL-1 beta levels at the same time. In the other hand, both handled and non-handled juvenile rats learned the aversive task, with no signal of immunosuppressant efect over interleukin 1 beta. However, basal levels of IL-1 beta were different between handled and non-handled animals in both ages, pointing a novel neuroimmunomodulation involvement to the NH model.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectHippocampusen
dc.subjectSistema nervoso centralpt_BR
dc.subjectInhibitory avoidanceen
dc.subjectHipocampopt_BR
dc.subjectIL-1 ben
dc.subjectInterleucina-1pt_BR
dc.subjectManipulação neonatalpt_BR
dc.subjectInterleukin 1 betaen
dc.subjectNeonatal handlingen
dc.subjectAprendizagem da esquivapt_BR
dc.titleEvidence of a relationship between aversive learning and hippocampal interleukin 1 beta levels in neonatal handled ratspt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coRocha, Cláudio Felipe Kolling dapt_BR
dc.identifier.nrb000881993pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentInstituto de Ciências Básicas da Saúdept_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2012pt_BR
dc.degree.graduationBiomedicinapt_BR
dc.degree.levelgraduaçãopt_BR


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