Navegação Produção Científica por Assunto "Systems biology"

Resultados 1-5 de 5

    • Computational biology helps understand how polyploid giant cancer cells drive tumor success 

      Casotti, Matheus Correia; Meira, Débora Dummer; Zetum, Aléxia Stefani Siqueira; Araújo, Bruno Cancian de; Silva, Danielle Ribeiro Campos da; Santos, Eldamária de Vargas Wolfgramm dos; Rodrigues, Fernanda Mariano Garcia de Souza; Paula, Flávia de; Santana, Gabriel Mendonça; Louro, Luana Santos; Alves, Lyvia Neves Rebello; Braga, Raquel Furlani Rocon; Trabach, Raquel Silva dos Reis; Bernardes, Sara Santos; Louro, Thomas Erik Santos; Chiela, Eduardo Cremonese Filippi; Lenz, Guido; Carvalho, Elizeu Fagundes de; Louro, Iúri Drumond (2023) [Artigo de periódico]
      Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation ...

    • Generation and evaluation of a genome-scale metabolic network model of synechococcus elongatus PCC7942 

      Triana Dopico, Julián; Montagud Aquino, Arnau; Siurana Paula, Maria; Fuente Herráiz, David; Urchueguía Fornes, Arantxa; Gamermann, Daniel; Torres Gavila, Francisco Javier; Tena Medialdea, José; Fernández de Córdoba Castellá, Pedro José; Urchueguía Schölzel, Javier Fermín (2014) [Artigo de periódico]
      The reconstruction of genome-scale metabolic models and their applications represent a great advantage of systems biology. Through their use as metabolic flux simulation models, production of industrially-interesting ...

    • Integrated analysis of the critical region 5p15.3-p15.2 associated with cri-du-chat syndrome 

      Corrêa, Thiago; Feltes, Bruno César; Riegel, Mariluce (2019) [Artigo de periódico]
      Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated ...

    • Network-based identification of altered stem cell pluripotency and calcium signaling pathways in metastatic melanoma 

      Oliveira, Ben Hur Neves de; Dalmaz, Carla; Zeidán-Chuliá, Fares (2018) [Artigo de periódico]
      Malignancy of cancer has been linked to distinct subsets of stem-like cells, the so-called cancer stem cells (CSCs), which persist during treatment and seem to lead to drug-resistant recurrence. Metastatic spread of cancer ...

    • Reverse engineering of Ewing Sarcoma regulatory network uncovers PAX7 and RUNX3 as master regulators associated with good prognosis 

      Dantas, Marcel da Câmara Ribeiro; Imparato, Danilo Oliveira; Dalmolin, Matheus Gibeke Siqueira; Farias, Caroline Brunetto de; Brunetto, Andre Tessainer; Jaeger, Mariane da Cunha; Roesler, Rafael; Sinigaglia, Marialva; Dalmolin, Rodrigo Juliani Siqueira (2021) [Artigo de periódico]
      Ewing Sarcoma (ES) is a rare malignant tumor occurring most frequently in adolescents and young adults. The ES hallmark is a chromosomal translocation between the chromosomes 11 and 22 that results in an aberrant transcription ...