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dc.contributor.authorSilva, Jhenifer N.pt_BR
dc.contributor.authorCalixto, Christianopt_BR
dc.contributor.authorBrito, Gisely Cristina Ramos dept_BR
dc.contributor.authorDaumas Filho, Carlos Renato de Oliveirapt_BR
dc.contributor.authorSilva, Ana Beatriz Walter Nuno dapt_BR
dc.contributor.authorCunha, Octávio Augusto Talyuli dapt_BR
dc.contributor.authorSampaio, Angélica Fernandes Arcanjopt_BR
dc.contributor.authorOliveira, Pedro Lagerblad dept_BR
dc.contributor.authorMoreira, Luciano A.pt_BR
dc.contributor.authorVaz Junior, Itabajara da Silvapt_BR
dc.contributor.authorLogullo, Carlospt_BR
dc.date.accessioned2024-09-06T06:37:35Zpt_BR
dc.date.issued2024pt_BR
dc.identifier.issn0021-9258pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/278456pt_BR
dc.description.abstractWolbachia pipientis is a maternally transmitted symbiotic bacterium that mainly colonizes arthropods, potentially affecting different aspects of the host’s physiology, e.g., reproduction, immunity, and metabolism. It has been shown that Wolbachia modulates glycogen metabolism in mosquito Aedes fluviatilis (Ae. fluviatilis). Glycogen synthesis is controlled by the enzyme GSK3, which is also involved in immune responses in both vertebrate and invertebrate organisms. Here we investigated the mechanisms behind immune changes mediated by glycogen synthase kinase β (GSK3β) in the symbiosis between Ae. fluviatilis and W. pipientis using a GSK3β inhibitor or RNAi-mediated gene silencing. GSK3β inhibition or knockdown increased glycogen content and Wolbachia population, together with a reduction in Relish2 and gambicin transcripts. Furthermore, knockdown of Relish2 or Caspar revealed that the immunodeficiency pathway acts to control Wolbachia numbers in the host. In conclusion, we describe for the first time the involvement of GSK3β in Ae. fluviatilis imune response, acting to control the Wolbachia endosymbiotic population.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe journal of biological chemistry. Amsterdam. Vol. 300, no. 6 (June 2024), 107272, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectWolbachiapt_BR
dc.subjectSymbiosisen
dc.subjectGlicogênio sintase quinase 3 betapt_BR
dc.subjectImmunometabolismen
dc.subjectGSK3βen
dc.subjectTranscrição genéticapt_BR
dc.subjectRelish2en
dc.subjectMetabolismo dos carboidratospt_BR
dc.subjectRespostas imunespt_BR
dc.subjectCélulas embrionáriaspt_BR
dc.subjectAedes fluviatilispt_BR
dc.titleImmunometabolic crosstalk in Aedes fluviatilis and Wolbachia pipientis symbiosispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001205475pt_BR
dc.type.originEstrangeiropt_BR


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