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dc.contributor.authorFranceschi, Vinicius Bonettipt_BR
dc.contributor.authorCaldana, Gabriel Dickinpt_BR
dc.contributor.authorPerin, Christianopt_BR
dc.contributor.authorHorn, Alexandre Mariantept_BR
dc.contributor.authorPeter, Camilapt_BR
dc.contributor.authorCybis, Gabriela Bettellapt_BR
dc.contributor.authorFerrareze, Patricia Aline Gröhspt_BR
dc.contributor.authorRotta, Liane Nancipt_BR
dc.contributor.authorCadegiani, Flávio Adsuarapt_BR
dc.contributor.authorZimerman, Ricardo Arielpt_BR
dc.contributor.authorThompson, Claudia Elizabethpt_BR
dc.date.accessioned2022-08-16T04:46:26Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2076-0817pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/246926pt_BR
dc.description.abstractAlmost a year after the COVID-19 pandemic had begun, new lineages (B.1.1.7, B.1.351, P.1, and B.1.617.2) associated with enhanced transmissibility, immunity evasion, and mortality were identified in the United Kingdom, South Africa, and Brazil. The previous most prevalent lineages in the state of Rio Grande do Sul (RS, Southern Brazil), B.1.1.28 and B.1.1.33, were rapidly replaced by P.1 and P.2, two B.1.1.28-derived lineages harboring the E484K mutation. To perform a genomic characterization from the metropolitan region of Porto Alegre, we sequenced viral samples to: (i) identify the prevalence of SARS-CoV-2 lineages in the region, the state, and bordering countries/regions; (ii) characterize the mutation spectra; (iii) hypothesize viral dispersal routes by using phylogenetic and phylogeographic approaches. We found that 96.4% of the samples belonged to the P.1 lineage and approximately 20% of them were assigned as the novel P.1.2, a P.1-derived sublineage harboring signature substitutions recently described in other Brazilian states and foreign countries. Moreover, sequences from this study were allocated in distinct branches of the P.1 phylogeny, suggesting multiple introductions in RS and placing this state as a potential diffusion core of P.1-derived clades and the emergence of P.1.2. It is uncertain whether the emergence of P.1.2 and other P.1 clades is related to clinical or epidemiological consequences. However, the clear signs of molecular diversity from the recently introduced P.1 warrant further genomic surveillance.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPathogens. Basel. Vol. 10, n. 8 (2021), Art. 988pt_BR
dc.rightsOpen Accessen
dc.subjectCOVID-19 (Doença)pt_BR
dc.subjectSevere acute respiratory syndrome coronavirus 2en
dc.subjectSARS-CoV-2pt_BR
dc.subjectInfectious diseasesen
dc.subjectHigh-throughput nucleotide sequencingen
dc.subjectDoenças infecciosaspt_BR
dc.subjectMolecular evolutionen
dc.subjectEvolução molecularpt_BR
dc.subjectMolecular epidemiologyen
dc.subjectEpidemiologia molecularpt_BR
dc.subjectFilogeniapt_BR
dc.subjectPhylogenyen
dc.titlePredominance of the SARS-CoV-2 lineage P.1 and its sublineage P.1.2 in patients from the metropolitan region of Porto Alegre, southern Brazil in March 2021pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001144778pt_BR
dc.type.originEstrangeiropt_BR


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