Synthesis and characterization of phloroglucinol derivatives
dc.contributor.advisor | Miron, Diogo dos Santos | pt_BR |
dc.contributor.author | Silva, Ivan Alejandro Brizio da | pt_BR |
dc.date.accessioned | 2022-05-24T04:44:11Z | pt_BR |
dc.date.issued | 2018 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/238915 | pt_BR |
dc.description.abstract | Phloroglucinol derivatives have been proved to have great pharmacological activity. Two acylated phloroglucinol were synthesized by Friedel-Crafts reaction and characterized by High Performance Liquid Chromatography (HPLC), Differential Scanning Calorimetry (DSC) , mass spectroscopy and Nuclear Magnetic Resonance (NMR) . The one-step synthesis was considered simple, giving a yield for 68% of monoacylphloroglucinol (MAPG) and 32% for diacylphloroglucinol (DAPG). Purification by crystallization of DAPG was more efficient than column chromatography of MAPG, showing great results after analysis. The analytical methods used in this work have proven to be simple and efficient to characterize both compounds, resulting in important information to proceed in the search of novel therapies. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.rights | Open Access | en |
dc.subject | Floroglucinol | pt_BR |
dc.subject | Monoacylphlorogluciol | en |
dc.subject | Cromatografia | pt_BR |
dc.subject | Diacylphloroglucinol | en |
dc.subject | Synthesis | en |
dc.subject | Métodos analíticos | pt_BR |
dc.subject | NMR | en |
dc.subject | HPLC | en |
dc.subject | DSC | en |
dc.title | Synthesis and characterization of phloroglucinol derivatives | pt_BR |
dc.type | Trabalho de conclusão de graduação | pt_BR |
dc.contributor.advisor-co | Gosmann, Grace | pt_BR |
dc.identifier.nrb | 001094804 | pt_BR |
dc.degree.grantor | Universidade Federal do Rio Grande do Sul | pt_BR |
dc.degree.department | Faculdade de Farmácia | pt_BR |
dc.degree.local | Porto Alegre, BR-RS | pt_BR |
dc.degree.date | 2018 | pt_BR |
dc.degree.graduation | Farmácia | pt_BR |
dc.degree.level | graduação | pt_BR |
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