Synthesis and evaluation of 2,3,4-substituted chiral oxazolidines against pediatric cancer cells
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Data
2018Orientador
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Abstract
It has previously been found a potent 2,3,4-oxazolidine series which was synthetized using the amino acid D-serine as the starting material. These compounds were assayed against cancer cell lines (HL60, JURKAT, LNCaP, MDA-MB-231, MCF-7, HCT-116) and their structure−activity relationship were investigated. The purpose of this work was to synthetize through seven steps, characterize and evaluate four 2,3,4-oxazolidines analogues against DAOY, SK-N-BE(2) and RD-ES pediatric cell lines. Compounds 5 ...
It has previously been found a potent 2,3,4-oxazolidine series which was synthetized using the amino acid D-serine as the starting material. These compounds were assayed against cancer cell lines (HL60, JURKAT, LNCaP, MDA-MB-231, MCF-7, HCT-116) and their structure−activity relationship were investigated. The purpose of this work was to synthetize through seven steps, characterize and evaluate four 2,3,4-oxazolidines analogues against DAOY, SK-N-BE(2) and RD-ES pediatric cell lines. Compounds 5a and 5b designed by the extension of the structure of 1 were the most potent, being active against all cell lines (IC50 ≤ 7 μM) and reduced ≥ 90% of cell viability at 25 μM for RD-ES and SK-N-BE(2). These derivatives were identified as novel anticancer agents including the novel direction towards pediatric cancer cells. ...
Instituição
Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Curso de Farmácia.
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TCC Farmácia (677)
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