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dc.contributor.authorLopes, Cassiane Elisabetept_BR
dc.contributor.authorDe Carli, Silviapt_BR
dc.contributor.authorRiboldi, Camila Impericopt_BR
dc.contributor.authorLorenzo, Cíntia dept_BR
dc.contributor.authorPanziera, Weldenpt_BR
dc.contributor.authorDriemeier, Davidpt_BR
dc.contributor.authorSiqueira, Franciele Mabonipt_BR
dc.date.accessioned2021-07-27T04:33:54Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2076-0817pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/224571pt_BR
dc.description.abstractPyometra is a life-threatening infectious disease that frequently affects bitches and queens. Although histopathological patterns of pyometra have been extensively explored, the microbiological aspects, such as bacteria pathogenicity, have not been correlated to microscopy endometrial lesions so far. In this study, these two pathological aspects of pyometra were analysed and correlated. Uterus fragments and intrauterine content samples were collected from pets diagnosed with pyometra (30) and submitted to histopathology analysis and bacterial culture, respectively. The degree of endometrial histopathological lesions in pyometra cases were classified as mild, moderate and severe. Thirty different bacteria isolates were identified from intrauterine content culture. Escherichia coli(E. coli) was pure isolated in 57.7% and highly related to severe endometrial lesions. Immunohistochemistry assay revealed the adhesion and invasion of this bacteria agent to the injured endometrium. Virulence aspects of these E. coli strains were explored, demonstrating biofilm formation ability and a set of virulence genes in most isolates. These results support the adaptive genetic and phenotypic advantages of E. coli for uterus infection, and justify the high frequency of this agent involved in pyometra cases.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPathogens. Basel. Vol. 10, no. 7 (July 2021), 833, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPiometrapt_BR
dc.subjectUterus infectionen
dc.subjectCompanion animalsen
dc.subjectDoencas uterinaspt_BR
dc.subjectEscherichia colipt_BR
dc.subjectBacteria isolationen
dc.subjectVirulence genesen
dc.subjectFatores de virulênciapt_BR
dc.subjectAnálise bacteriológicapt_BR
dc.subjectHistopathologyen
dc.subjectHistopatologiapt_BR
dc.subjectEnPECen
dc.subjectCãespt_BR
dc.subjectGatospt_BR
dc.titlePet pyometra : correlating bacteria pathogenicity to endometrial histological changespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001128572pt_BR
dc.type.originEstrangeiropt_BR


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