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dc.contributor.authorGuim, Tainã Normantonpt_BR
dc.contributor.authorCecco, Bianca Santana dept_BR
dc.contributor.authorLaisse, Cláudio João Mourãopt_BR
dc.contributor.authorSchmitt, Bernardopt_BR
dc.contributor.authorHenker, Luan Cleberpt_BR
dc.contributor.authorVieira, Camila da Rosapt_BR
dc.contributor.authorDriemeier, Davidpt_BR
dc.contributor.authorPavarini, Saulo Petinattipt_BR
dc.contributor.authorSonne, Lucianapt_BR
dc.date.accessioned2019-11-15T03:52:50Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1676-546Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/201868pt_BR
dc.description.abstractExtra-skeletal osteosarcoma is a malignant mesenchymal neoplasm that originates from soft tissue. This tumor occurs spontaneously in dogs, but there are few cases described in the literature. The objective of this study was to describe the epidemiological and pathologic features of extra-skeletal osteosarcoma in 36 dogs. Cases diagnosed as osteosarcoma affecting dogs (n=216), during 2006 to 2016 were reviewed. Of these, 36 cases were diagnosed as extra-skeletal osteosarcoma. The mean age of affected dogs was 10.4 years, and the mean weight was 19.5kg. No breed predisposition was observed. The most frequently affected sites were the mammary glands (80.6%; 29/36), subcutaneous tissue (5.6%; 2/36), liver (5.6%; 2/36), spleen (2.8%; 1/36), omentum (2.8%; 1/36), and kidney (2.8%; 1/36). Histological examination revealed that 61.1% (22/36) of the tumors were osteoblastic, 33.3% (12/36) chondroblastic, 2.8% (1/36) fibroblastic, and 2.8% (1/36) were giant cell-rich osteosarcomas. Histological grade II and III were the most frequent. Lymph node metastases were observed in 21.4% (3/14) of the cases of mammary gland osteosarcoma. Distant metastases were observed in 23.1% (3/13) of cases by diagnostic imaging and in 71.4% (5/7) during autopsy. Metastases were observed in the lungs (57.1%; 4/7), liver (14.3%; 1/7), spleen (14.3%; 1/7), and in multiple sites (14.3%; 1/7). Pulmonary metastases were more frequently observed in cases of mammary gland osteosarcoma.en
dc.description.abstractOsteossarcoma extraesquelético é uma neoplasma mesenquimal maligno que se origina de tecidos moles. O neoplasma ocorre espontaneamente em cães, mas há poucos casos descritos na literatura. Este trabalho teve como objetivo descrever os aspectos epidemiológicos e patológicos do osteossarcoma extraesquelético em 36 cães. Casos diagnosticados de osteossarcoma afetando cães (n=216), durante 2006 a 2016 foram revisados. Deste total, 36 casos tiveram diagnóstico de osteossarcoma extraesquelético. A média de idade foi de 10,4 anos, não houve predisposição racial e o peso médio foi de 19,5kg. Os locais acometidos foram glândula mamária (80,6%; 29/36), tecido subcutâneo (5,6%; 2/36), fígado (5,6%; 2/36), baço (2,8%; 1/36), omento (2,8%; 1/36) e rim (2,8%; 1/36). Na histologia, 61,1% (22/36) eram osteoblásticos, 33,3% (12/36) eram condroblásticos, 2,8% (1/36) eram fibroblásticos e 2,8% (1/36) eram ricos em células gigantes. Os graus histológicos II e III foram os mais frequentes. Metástases nodais estavam presentes em 21,4% (3/14) dos casos que ocorreram na mama. Metástases distantes foram constatadas em 23,1% (3/13) dos casos por exames de imagem e em 71,4% (5/7) dos casos pela autópsia. Os locais de metástases foram pulmões (57,1%; 4/7), fígado (14,3%; 1/7), baço (14,3%; 1/7) e em múltiplos sítios (14,3%; 1/7). Metástases pulmonares foram mais frequentes em cadelas com osteossarcoma de glândula mamária.pt_BR
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofSemina : ciências agrárias. Londrina, PR. Vol. 40, n. 6, Supl. 2 (2019), p. 3089-3098pt_BR
dc.rightsOpen Accessen
dc.subjectOsteossarcomapt_BR
dc.subjectMammary glanden
dc.subjectCãespt_BR
dc.subjectNeoplasms sarcomasen
dc.subjectSoft tissuesen
dc.subjectHistopatologiapt_BR
dc.subjectEpidemiologiapt_BR
dc.titleEpidemiological and pathologic aspects of extra-skeletal osteosarcoma in dogspt_BR
dc.title.alternativeAspectos epidemiológicos e patológicos do osteossarcoma extraesquelético em cães pt
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001104219pt_BR
dc.type.originNacionalpt_BR


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