Navegação Ciências Exatas e da Terra por Assunto "Tacrina"
Resultados 1-2 de 2
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Lewis acid promoted Friedländer condensation reactions between anthranilonitrile and ketones for the synthesis of tacrine and its analoques
(2009) [Artigo de periódico]Nesse trabalho estudou-se a reação de ciclodesidratação entre antranilonitrila e várias cetonas na presença de diferentes ácidos de Lewis não reportados na literatura, para a obtenção de 9-amino-1,2,3,4-tetrahidroacridinas. ... -
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors
(2013) [Artigo de periódico]A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. The key step ...
