Navegação Ciências Exatas e da Terra por Autor "Konrath, Eduardo Luis"
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Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors
Costa, Jessie Sobieski da; Lopes, João Paulo Bizarro; Russowsky, Dennis; Petzhold, Cesar Liberato; Borges, Antônio César de Amorim; Ceschi, Marco Antonio; Konrath, Eduardo Luis; Batassini, Cristiane; Lunardi, Paula Santana; Goncalves, Carlos Alberto Saraiva (2013) [Artigo de periódico]A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. The key step ...