Navegação Ciências Exatas e da Terra por Autor "Gomes, Julia do Amaral"

Resultados 1-3 de 3

    • Comparative genomics identifies putative interspecies mechanisms underlying crbn-sall4-linked thalidomide embryopathy 

      Kowalski, Thayne Woycinck; Garcia, Gabriela Barreto Caldas; Gomes, Julia do Amaral; Fraga, Lucas Rosa; Faccini, Lavinia Schuler; Recamonde-Mendoza, Mariana; Paixão Côrtes, Vanessa Rodrigues; Vianna, Fernanda Sales Luiz (2021) [Artigo de periódico]
      The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still ...

    • CRL4-Cereblon complex in Thalidomide Embryopathy : a translational investigation 

      Kowalski, Thayne Woycinck; Gomes, Julia do Amaral; Garcia, Gabriela Barreto Caldas; Fraga, Lucas Rosa; Paixão Côrtes, Vanessa Rodrigues; Recamonde-Mendoza, Mariana; Sanseverino, Maria Teresa Vieira; Faccini, Lavinia Schuler; Vianna, Fernanda Sales Luiz (2020) [Artigo de periódico]
      The Cereblon-CRL4 complex has been studied predominantly with regards to thalidomide treatment of multiple myeloma. Nevertheless, the role of Cereblon-CRL4 in Thalidomide Embryopathy (TE) is still not understood. Not all ...

    • A new strategy for the old challenge of thalidomide : systems biology prioritization of potential immunomodulatory drug (IMiD)-targeted transcription factors 

      Kowalski, Thayne Woycinck; Feira, Mariléa Furtado; Lord, Vinicius Oliveira; Gomes, Julia do Amaral; Giudicelli, Giovanna Câmara; Fraga, Lucas Rosa; Sanseverino, Maria Teresa Vieira; Recamonde-Mendoza, Mariana; Faccini, Lavinia Schuler; Vianna, Fernanda Sales Luiz (2023) [Artigo de periódico]
      Several molecular mechanisms of thalidomide embryopathy (TE) have been investigated, from anti-angiogenesis to oxidative stress to cereblon binding. Recently, it was discovered that thalidomide and its analogs, named ...