Browsing Journal Articles by Subject "Systems biology"
Now showing items 1-5 of 5
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Computational biology helps understand how polyploid giant cancer cells drive tumor success
(2023) [Journal article]Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation ... -
Generation and evaluation of a genome-scale metabolic network model of synechococcus elongatus PCC7942
(2014) [Journal article]The reconstruction of genome-scale metabolic models and their applications represent a great advantage of systems biology. Through their use as metabolic flux simulation models, production of industrially-interesting ... -
Integrated analysis of the critical region 5p15.3-p15.2 associated with cri-du-chat syndrome
(2019) [Journal article]Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated ... -
Network-based identification of altered stem cell pluripotency and calcium signaling pathways in metastatic melanoma
(2018) [Journal article]Malignancy of cancer has been linked to distinct subsets of stem-like cells, the so-called cancer stem cells (CSCs), which persist during treatment and seem to lead to drug-resistant recurrence. Metastatic spread of cancer ... -
Reverse engineering of Ewing Sarcoma regulatory network uncovers PAX7 and RUNX3 as master regulators associated with good prognosis
(2021) [Journal article]Ewing Sarcoma (ES) is a rare malignant tumor occurring most frequently in adolescents and young adults. The ES hallmark is a chromosomal translocation between the chromosomes 11 and 22 that results in an aberrant transcription ...