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dc.contributor.advisorBau, Claiton Henrique Dottopt_BR
dc.contributor.authorBandeira, Cibele Edompt_BR
dc.date.accessioned2018-11-09T02:46:03Zpt_BR
dc.date.issued2016pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/184506pt_BR
dc.description.abstractBackground: The etiology of Alcohol Dependence is multifactorial, resulting from the interplay of environmental and genetic factors, including variants in neurotransmission related genes. In this sense, the Soluble NSF-Attachment Protein Receptors (SNARE) complex, which acts on neurotransmitter release, could play an important role in this disorder. The aim of the present study was to evaluate polymorphisms in SNARE complex genes (STX1A rs2228607; SYT1 rs1880867 and rs2251214; VAMP2 26 bp Ins/Del; SNAP25 rs6108461 and rs8636) in relation to Alcohol Dependence susceptibility. Methods: The sample comprised 115 men under inpatient treatment for with Alcohol Dependence and 308 non-dependent controls. Additionally, 278 men with Attention-Deficit/Hyperactivity Disorder (ADHD), of which 35 presented comorbidity with Alcohol Dependence were subsequently evaluated in order to replicate the association. Results: A nominal association was found between the VAMP2 26 bp Ins/Del polymorphism and susceptibility to Alcohol Dependence, where the Ins/Ins genotype showed a risk to this disorder (p = 0.012; OR = 2.21). This result was supported by the ADHD replication sample, where the Ins/Ins genotype was also more frequent among Alcohol Dependent cases (p = 0.008; OR = 5.26). Other polymorphisms and haplotype analyses did not reveal significant differences between cases and controls. Conclusion: Overall, the present study suggests that VAMP2 26 bp Ins/Del polymorphism, previously associated with ADHD, is also implicated in Alcohol Dependence susceptibility.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoporpt_BR
dc.rightsOpen Accessen
dc.subjectAlcoolismopt_BR
dc.subjectSNAREen
dc.subjectAlcohol dependenceen
dc.subjectVAMP2en
dc.titleComplexo SNARE na susceptibilidade ao transtorno por uso de álcoolpt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coCupertino, Renata Bassopt_BR
dc.identifier.nrb001005732pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentInstituto de Biociênciaspt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2016pt_BR
dc.degree.graduationCiências Biológicas: Bachareladopt_BR
dc.degree.levelgraduaçãopt_BR


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