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dc.contributor.advisorBeck, Ruy Carlos Ruverpt_BR
dc.contributor.authorChaves, Paula dos Santospt_BR
dc.date.accessioned2018-11-07T02:46:31Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/184405pt_BR
dc.description.abstractCarvedilol (CV) has been used for the management of heart failure, hypertension and coronary artery diseases. However, it presents low oral bioavailability (25-35%). The objective of this study was to develop carvedilol-loaded nanocapsules (NC) in order to achieve a controlled drug release aiming the development of dosage forms to be administered by alternative routes. Poly(ε-caprolactone) (PCL) and Eudragit RS100 (EUD) were evaluated as polymeric wall. Nanocapsules (CV-PCL-NC and CV-EUD-NC) were prepared by interfacial deposition of preformed polymer method and characterized according to particle size and polydispersity, zeta potential, pH, drug content, encapsulation efficiency, morphology, backscattering analysis, presence of nanocrystals and drug release profile. Thermal analysis was performed to evaluate compatibility between CV and excipients. All formulations showed nanometric diameters with low polydispersity and pH slightly acid The zeta potential was positive and negative for CV-EUD-NC and CV-PCL-NC, respectively. The drug content was close to theoretical value (0.5 mg.mL-1) for both formulations and the encapsulation efficiency was higher than 87% and 99% for CV-EUD-NC and CV-PCL-NC, respectively. Nanocapsules were spherical-shaped and their suspensions showed no significant phenomena of physical instability. Drug release was controlled by both developed formulations. However, CV-PCL-NC showed phase separation during storage and an interaction between the drug and the surfactant was evidenced by thermal analysis. This study demonstrated the feasibility to encapsulate CV in nanocapsules to achieve a controlled release rate. Further studies will be carried out to explore alternatives routes of administration using these formulations.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectNanocápsulaspt_BR
dc.subjectCarvedilolen
dc.subjectCarvedilolpt_BR
dc.subjectNanocapsulesen
dc.subjectLiberação de fármacospt_BR
dc.subjectEudragit RS100en
dc.subjectPoly(ε-caprolactone)en
dc.subjectDrug releaseen
dc.titleCarvedilol-loaded nanocapsules : physicochemical characterization and in vitro drug releasept_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coOurique, Aline Ferreirapt_BR
dc.identifier.nrb000904985pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2013pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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