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dc.contributor.advisorRohe, Paulo M.pt_BR
dc.contributor.authorJunqueira, Dennis Maletichpt_BR
dc.contributor.authorMedeiros, Rubia Marília dept_BR
dc.date.accessioned2017-05-26T02:30:14Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/158605pt_BR
dc.description.abstractSubtype C human immunodeficiency vírus type 1 (HIV-1) is rapidly diversifying among populations, which display extensiva polymorphism of genes encoding class I human leukocyte antigen (HLA) proteins, as detected in different regions of the world. Broadly conserved HIV-1 cytotoxic T cell (CTL) epitopes considering 128 subtype C externai glycoprotein gp120 sequences selected from GenBank were identified to A*0201, A*0301, A*1101 and 8*07 HLA alleles using Epijen software. NetChop allowed to predict proteasome cleavage followed by prediction of binding to transport associated with antigen processing on TapPred. Glycosylation and positively selected sites within epitope sequences were also observed. Furthermore, three-dimensional structures of subtype C gp120 were predicted from consensus sequences in PHYRE and the PYMOL software was used to verify positions occupied by conserved epitopes. Finally, we predicted discontinuous B cell epitopes in DiscoTope 1.2. There is a recognized evolutionary force of HIV-1 to escape from B cells and CTL responses mutating sites that can negatively select the viral population. ' These types of analyses could be useful to understand HIV-1 epidemiology associated with polymorphisms in HLA alleles frequent in a determined region. 1t is expected that such knowledge may provide additional support for vaccine development.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.rightsOpen Accessen
dc.subjectSubtype Cen
dc.subjectHIV-1pt_BR
dc.subjectGlicoproteinaspt_BR
dc.subjectBioinformaticsen
dc.subjectEpitopeen
dc.subjectgp120en
dc.subjectHLAen
dc.titleHuman Immunodeficiency virus type 1 subtype C external glycoproteins epitopes : in silico predictionspt_BR
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coAlmeida, Sabrina Esteves de Matospt_BR
dc.contributor.advisor-coSpilki, Fernando Rosadopt_BR
dc.identifier.nrb000679420pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentInstituto de Ciências Básicas da Saúdept_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2008pt_BR
dc.degree.graduationCiências Biológicas: Ênfase Molecular, Celular e Funcional: Bachareladopt_BR
dc.degree.levelgraduaçãopt_BR


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