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dc.contributor.authorTriana Dopico, Juliánpt_BR
dc.contributor.authorMontagud Aquino, Arnaupt_BR
dc.contributor.authorSiurana Paula, Mariapt_BR
dc.contributor.authorFuente Herráiz, Davidpt_BR
dc.contributor.authorUrchueguía Fornes, Arantxapt_BR
dc.contributor.authorGamermann, Danielpt_BR
dc.contributor.authorTorres Gavila, Francisco Javierpt_BR
dc.contributor.authorTena Medialdea, Josépt_BR
dc.contributor.authorFernández de Córdoba Castellá, Pedro Josépt_BR
dc.contributor.authorUrchueguía Schölzel, Javier Fermínpt_BR
dc.date.accessioned2014-11-12T02:14:04Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn2218-1989pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/106734pt_BR
dc.description.abstractThe reconstruction of genome-scale metabolic models and their applications represent a great advantage of systems biology. Through their use as metabolic flux simulation models, production of industrially-interesting metabolites can be predicted. Due to the growing number of studies of metabolic models driven by the increasing genomic sequencing projects, it is important to conceptualize steps of reconstruction and analysis. We have focused our work in the cyanobacterium Synechococcus elongatus PCC7942, for which several analyses and insights are unveiled. A comprehensive approach has been used, which can be of interest to lead the process of manual curation and genome-scale metabolic analysis. The final model, iSyf715 includes 851 reactions and 838 metabolites. A biomass equation, which encompasses elementary building blocks to allow cell growth, is also included. The applicability of the model is finally demonstrated by simulating autotrophic growth conditions of Synechococcus elongatus PCC7942.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofMetabolites. Basel. Vol. 4, no. 3 (sept. 2014), p. 680-698pt_BR
dc.rightsOpen Accessen
dc.subjectGenome-scale metabolic network reconstructionen
dc.subjectSistemas biológicospt_BR
dc.subjectGenomapt_BR
dc.subjectSystems biologyen
dc.subjectRedespt_BR
dc.subjectMetabolic pathwaysen
dc.subjectFlux balance analysisen
dc.subjectBiological databasesen
dc.titleGeneration and evaluation of a genome-scale metabolic network model of synechococcus elongatus PCC7942pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000933834pt_BR
dc.type.originEstrangeiropt_BR


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