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dc.contributor.authorLimandri, Silvina P.pt_BR
dc.contributor.authorde Vera Gomis, Pablopt_BR
dc.contributor.authorFadanelli Filho, Raul Carlospt_BR
dc.contributor.authorNagamine, Luiz Carlos Camargo Mirandapt_BR
dc.contributor.authorSilva, Alexandre Mello de Paulapt_BR
dc.contributor.authorGarcía-Molina, Rafaelpt_BR
dc.contributor.authorBehar, Monipt_BR
dc.contributor.authorAbril Sanches, Isabelpt_BR
dc.date.accessioned2014-08-26T09:26:33Zpt_BR
dc.date.issued2014pt_BR
dc.identifier.issn1539-3755pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/101866pt_BR
dc.description.abstractIon-beam cancer therapy is a promising technique to treat deep-seated tumors; however, for an accurate treatment planning, the energy deposition by the ions must be well known both in soft and hard human tissues. Although the energy loss of ions in water and other organic and biological materials is fairly well known, scarce information is available for the hard tissues (i.e., bone), for which the current stopping power information relies on the application of simple additivity rules to atomic data. Especially, more knowledge is needed for the main constituent of human bone, calcium hydroxyapatite (HAp), which constitutes 58% of its mass composition. In this work the energy loss ofHandHe ion beams in HAp films has been obtained experimentally. The experiments have been performed using the Rutherford backscattering technique in an energy range of 450–2000 keV for H and 400–5000 keV for He ions. These measurements are used as a benchmark for theoretical calculations (stopping power and mean excitation energy) based on the dielectric formalism together with the MELF-GOS (Mermin energy loss function-generalized oscillator strength) method to describe the electronic excitation spectrum of HAp. The stopping power calculations are in good agreement with the experiments. Even though these experimental data are obtained for low projectile energies compared with the ones used in hadron therapy, they validate the mean excitation energy obtained theoretically, which is the fundamental quantity to accurately assess energy deposition and depth-dose curves of ion beams at clinically relevant high energies. The effect of the mean excitation energy choice on the depth-dose profile is discussed on the basis of detailed simulations. Finally, implications of the present work on the energy loss of charged particles in human cortical bone are remarked.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPhysical review. E, Statistical, nonlinear, and soft matter physics. Vol. 89, no. 2 (Feb. 2014), 022703, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectPerda de energia de particulaspt_BR
dc.subjectFeixes de íonspt_BR
dc.titleEnergy deposition of H and He ion beams in hydroxyapatite films : a study with implications for ion-beam cancer therapypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000916042pt_BR
dc.type.originEstrangeiropt_BR


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