Background: To date, no biomarker has been able to predict antidepressant response at an early blockade of norepinephrine or serotonin uptake. The transient nocturnal increase in plasma melatonin levels is upregulated by ...

Background: Even though light is considered the main cue that entrains inner biological rhythms according to circadian environmental rhythms, social organizations have the capacity to take the body “out of sync”. An emergent ...

Objective: To describe the initial steps in the development and validation of a new self-reported instrument designed to assess daily rhythms of mood symptoms, namely, the Mood Rhythm Instrument. Methods: A multidisciplinary ...