Browsing by Subject "Rat brain"

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Chronic postnatal administration of methylmalonic acid provokes a decrease of myelin content and ganglioside N-acetylneuramic acid concentration in cerebrum of young rats

Brusque, Ana Maria; Rotta, Liane Nanci; Pettenuzzo, Letícia Ferreira; Junqueira, Debora; Schwarzbold, Carolina Vargas; Wyse, Angela Terezinha de Souza; Wannmacher, Clovis Milton Duval; Dutra Filho, Carlos Severo; Wajner, Moacir (2001) [Journal article]

Levels of methylmalonic acid (MMA) comparable to those of human methylmalonic acidemia were achieved in blood (2-2.5 mmol/l) and brain (1.35 µmol/g) of rats by administering buffered MMA, pH 7.4, subcutaneously twice a day ...