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Characterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysis

dc.contributor.authorMendez, Andreas Sebastian Loureiropt_BR
dc.contributor.authorMantovani, Lucianopt_BR
dc.contributor.authorBarbosa, Fábio de Souzapt_BR
dc.contributor.authorSayago, Carla T.M.pt_BR
dc.contributor.authorGarcia, Cassia Virginiapt_BR
dc.contributor.authorPaula, Fávero Reisdorferpt_BR
dc.contributor.authorSilva, Fabiana Ernestina Barcellos dapt_BR
dc.contributor.authorDenardin, Elton Luis Gasparottopt_BR
dc.contributor.authorSchapoval, Elfrides Eva Schermanpt_BR
dc.date.accessioned2013-07-02T01:43:46Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/72934pt_BR
dc.description.abstractDoripenem was characterized through physicochemical and spectroscopic techniques, as well as thermal analysis. TLC (Rf = 0.62) and HPLC (rt = 7.4 min) were found to be adequate to identify the drug. UV and infrared spectra showed similar profile between doripenem bulk and standard. The 1H and 13C NMR analysis revealed chemical shifts that allowed identifying the drug. Thermal analysis demonstrated three steps with mass loss, at 128, 178 and 276 oC. The work was successfully applied to qualitative analysis of doripenem, showing the reported methods can be used for physicochemical characterization of doripenem.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofQuímica nova. São Paulo. Vol. 34, n. 9 (2011), p. 1634-1638pt_BR
dc.rightsOpen Accessen
dc.subjectQualitative analysisen
dc.subjectDoripenempt_BR
dc.subjectPhysicochemical methodsen
dc.subjectAntibióticospt_BR
dc.subjectMétodos físico-químicos de análisept_BR
dc.titleCharacterization of the antibiotic doripenem using physicochemical methods : chromatography, spectrophotometry, spectroscopy and thermal analysispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000792844pt_BR
dc.type.originNacionalpt_BR


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