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dc.contributor.authorFriedrisch, Joao Ricardopt_BR
dc.contributor.authorBarros, Elvino José Guardãopt_BR
dc.contributor.authorManfro, Roberto Cerattipt_BR
dc.contributor.authorBittar, Christina Matzenbacherpt_BR
dc.contributor.authorSilla, Lucia Mariano da Rochapt_BR
dc.date.accessioned2012-12-28T01:35:45Zpt_BR
dc.date.issued2003pt_BR
dc.identifier.issn1516-8484pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/62031pt_BR
dc.description.abstractEmbora a anemia falciforme e as síndromes falciformes freqüentemente causem várias alterações funcionais renais, não é comum a insuficiência renal terminal. Nestes casos, o transplante renal é uma alternativa que se acompanha de resultados comparáveis aos obtidos em receptores sem hemoglobinopatias. Esta estratégia terapêutica tem sido, no entanto, pouco relatada para portadores de hemoglobinopatia SC. Este relato descreve a evolução de dois pacientes portadores de hemoglobinopatia SC que foram submetidos ao transplante renal. No momento do transplante ambos apresentavam severa anemia e crises dolorosas freqüentes. Os pacientes evoluíram com boa função do enxerto, parâmetros hematológicos quase normais e praticamente assintomáticos do ponto de vista da hemoglobinopatia, treze e oito anos após o transplante. Estes casos ilustram que a insuficiência renal terminal causada pela hemoglobinopatia SC pode ser tratada com sucesso pelo transplante renal, não só do ponto de vista renal, propriamente dito, mas também em termos de sua doença hematológica.pt_BR
dc.description.abstractAlthough sickle cell anemia and sickle cell disease produce a variety of functional renal abnormalities they uncommonly cause end stage renal failure. Renal transplantation has been a successful alternative for the treatment of the rare terminal chronic renal failure with outcomes comparable with non-sickle recipients. This approach, however, has not been often described on patients with renal failure associated with SC hemoglobinopathy. Here we report the outcomes of two patients with chronic renal failure due to SC hemoglobinopathies who underwent renal transplantation. At the time of the transplantation they were both severely anemic and had frequent vasoocclosive pain crises. Both patients evolved with good allograft function, near normal hematological parameters, and very rare pain crisis, thirteen and eight years after transplant. These cases illustrate that terminal renal failure due to SC hemoglobinopathy can be successfully managed by renal transplantation and satisfactory longterm results are achievable not only in terms of renal allograft function but also of their hematological condition.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofRevista brasileira de hematologia e hemoterapia = Brazilian journal of hematology and hemotherapy. Vol. 25, n. 2 (abr./jun. 2003), p. 111-114pt_BR
dc.rightsOpen Accessen
dc.subjectSC hemoglobinopathyen
dc.subjectHemoglobinopatiaspt_BR
dc.subjectAnemia falciformept_BR
dc.subjectChronic renal failureen
dc.subjectRenal transplantationen
dc.subjectInsuficiência renalpt_BR
dc.subjectTransplante de rimpt_BR
dc.titleLong-term follow-up of kidney allografts in patients with sickle cell hemoglobinopathypt_BR
dc.title.alternativeTransplante renal na anemia falciforme pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000431692pt_BR
dc.type.originNacionalpt_BR


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