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dc.contributor.authorLeite, Elma Limapt_BR
dc.contributor.authorAraujo, Wydemberg Jose dept_BR
dc.contributor.authorVieira, Tatiana Reginapt_BR
dc.contributor.authorZenato, Karoline Silvapt_BR
dc.contributor.authorVasconcelos, Priscylla Carvalhopt_BR
dc.contributor.authorCibulski, Samuel Paulopt_BR
dc.contributor.authorGivisiez, Patrícia Emília Navespt_BR
dc.contributor.authorCardoso, Marisa Ribeiro de Itapemapt_BR
dc.contributor.authorOliveira, Celso José Bruno dept_BR
dc.date.accessioned2021-03-09T04:49:00Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn2213-7165pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/218515pt_BR
dc.description.abstractObjectives: To investigate the genetic context of colistin resistance in anmcr-9-harbouring Salmonella Typhimurium ST19 strain from swine in Brazil. Methods: Minimum inhibitory concentrations (MIC) to colistin were determined by broth microdilution. Whole-genome sequencing was performed on an Illumina MiSeq system, followed by de novo genome assembly using SPAdes 1.13.1. The draft genome sequence was annotated in Prokka using KBase online server. Downstream analyses for resistome and plasmid detection were performed using online tools available at the Center for Genomic Epidemiology. The strain was typed in silico using MLST 2.0. Phylogenetic analysis involving 24 other genomes of Salmonella Typhimurium ST19 and mcr-9-harbouring Salmonella Typhimurium isolated from humans, livestock and foodstuff in different regions was also performed. Results: Assembly of the draft genome resulted in 5245 protein-coding sequences, 14 rRNAs, 83 tRNAs and a GC content of 51.81%. The strain was identified as Salmonella Typhimurium ST19 harbouring a 265.5-kb pN1566-2 plasmid carrying genes encoding resistance to colistin (mcr-9.1), aminoglycosides (aadA1), tetracycline [tet(C)] and sulfonamides (sul1). Our findings indicate that the Salmonella Typhimurium ST19 strain in this study showed low genetic variability compared with Salmonella Typhimurium ST19 isolated from swine and poultry in Brazil, and was less related to those reported in other countries. Conclusions: This is the first reported genome of a phenotypically colistin-resistant Salmonella Typhimurium harbouring the mcr-9 variant in Brazilian livestock. This genome will aid global investigations on epidemiological and evolutionary aspects of plasmid-mediated colistin resistance and the role of colistin-resistant Salmonella Typhimurium ST19 lineage as a zoonotic pathogen.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of global antimicrobial resistance. Amsterdam. Vol. 23 (Dec. 2020), p. 394-397pt_BR
dc.rightsOpen Accessen
dc.subjectWhole-genome sequencingen
dc.subjectSalmonella typhimuriumpt_BR
dc.subjectColistin resistanceen
dc.subjectSequenciamento completo do genomapt_BR
dc.subjectPolymyxinen
dc.subjectResistência a antimicrobianospt_BR
dc.subjectmcr-9en
dc.subjectColistinapt_BR
dc.subjectFilogeniapt_BR
dc.subjectSuínospt_BR
dc.titleFirst reported genome of an mcr-9-mediated colistin-resistant Salmonella Typhimurium isolate from Brazilian livestockpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001122303pt_BR
dc.type.originEstrangeiropt_BR


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