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dc.contributor.authorSubramanian, Lakshmipt_BR
dc.contributor.authorCalcagnotto, Maria Elisapt_BR
dc.contributor.authorParedes, Mercedes F.pt_BR
dc.date.accessioned2020-11-20T04:15:04Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn1662-5102pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/215275pt_BR
dc.description.abstractCreating a functional cerebral cortex requires a series of complex and well-coordinated developmental steps. These steps have evolved across species with the emergence of cortical gyrification and coincided with more complex behaviors. The presence of diverse progenitor cells, a protracted timeline for neuronal migration and maturation, and diverse neuronal types are developmental features that have emerged in the gyrated cortex. These factors could explain how the human brain has expanded in size and complexity. However, their complex nature also renders new avenues of vulnerability by providing additional cell types that could contribute to disease and longer time windows that could impact the composition and organization of the cortical circuit. We aim to discuss the unique developmental steps observed in human corticogenesis and propose how disruption of these species-unique processes could lead to malformations of cortical development.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in cellular neuroscience. Lausanne. Vol. 13 (Jan. 2020), 576, 17 p.pt_BR
dc.rightsOpen Accessen
dc.subjectMalformações do desenvolvimento corticalpt_BR
dc.subjectHuman cortical developmenten
dc.subjectCórtex cerebralpt_BR
dc.subjectMCD = malformation of cortical developmenten
dc.subjectCrescimento e desenvolvimentopt_BR
dc.subjectProgenitors cellsen
dc.subjectNeuronal migrationen
dc.subjectCélulas-troncopt_BR
dc.subjectNeurogliapt_BR
dc.subjectConnectivityen
dc.titleCortical malformations : lessons in human brain developmentpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001116782pt_BR
dc.type.originEstrangeiropt_BR


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