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dc.contributor.authorGarcia-Basteiro, Alberto L.pt_BR
dc.contributor.authorDiNardo, Andrew R.pt_BR
dc.contributor.authorSaavedra, Belénpt_BR
dc.contributor.authorSilva, Denise Rossatopt_BR
dc.contributor.authorPalmero, Domingo Juanpt_BR
dc.contributor.authorGegia, Medeapt_BR
dc.contributor.authorMigliori, Giovanni Battistapt_BR
dc.contributor.authorDuarte, Raquelpt_BR
dc.contributor.authorMambuque, Edson T.pt_BR
dc.contributor.authorCentis, Rosellapt_BR
dc.contributor.authorCuevas, Eduardo Luispt_BR
dc.contributor.authorIzco, Santiagopt_BR
dc.contributor.authorTheron, Grantpt_BR
dc.date.accessioned2020-11-05T04:07:20Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn2531-0437pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/214653pt_BR
dc.description.abstractThe goals of the End TB strategy, which aims to achieve a 90% reduction in tuberculosis (TB) incidence and a 95% reduction in TB mortality by 2035, will not be achieved without new tools to fight TB. These include improved point of care (POC) diagnostic tests that are meant to be delivered at the most decentralised levels of care where the patients make the initial contact with the health system, as well as within the community. These tests should be able to be performed on an easily accessible sample and provide results in a timely manner, allowing a quick treatment turnaround time of a few minutes or hours (in a single clinical encounter), hence avoiding patient loss-to-follow-up. There have been exciting developments in recent years, including the WHO endorsement of Xpert MTB/RIF, Xpert MTB/RIF Ultra, loop-mediated isothermal amplification (TB-LAMP) and lateral flow lipoarabinomannan (LAM). However, these tests have limitations that must be overcome before they can be optimally applied at the POC. Furthermore, worrying short- to medium-term gaps exist in the POC diagnostic test development pipeline. Thus, not only is better implementation of existing tools and algorithms needed, but new research is required to develop new POC tests that allow the TB community to truly make an impact and find the ‘‘missed TB cases’’.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPulmonology. [Barcelona]. Vol. 24, no. 2 (2018), p. 73-85pt_BR
dc.rightsOpen Accessen
dc.subjectTuberculosept_BR
dc.subjectTuberculosisen
dc.subjectPoint-of-careen
dc.subjectDiagnósticopt_BR
dc.subjectDiagnosisen
dc.subjectTestes de sensibilidade microbianapt_BR
dc.subjectSistemas automatizados de assistência junto ao leitopt_BR
dc.subjectTarget product profileen
dc.subjectTestes imediatospt_BR
dc.subjectXperten
dc.subjectLAMen
dc.subjectSinais e sintomaspt_BR
dc.subjectRevisãopt_BR
dc.subjectNAATen
dc.titlePoint of care diagnostics for tuberculosispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001106318pt_BR
dc.type.originEstrangeiropt_BR


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