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dc.contributor.authorVeiga, Caroline Perinazzo dapt_BR
dc.contributor.authorMiczek, Klaus Alexanderpt_BR
dc.contributor.authorLucion, Aldo Boltenpt_BR
dc.contributor.authorAlmeida, Rosa Maria Martins dept_BR
dc.date.accessioned2010-04-24T04:15:48Zpt_BR
dc.date.issued2007pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/21218pt_BR
dc.description.abstractSerotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (June 2007), p. 825-830pt_BR
dc.rightsOpen Accessen
dc.subjectPrefrontal cortexen
dc.subjectSerotonina : Comportamento : Agressividade : Rataspt_BR
dc.subjectReceptores de serotoninapt_BR
dc.subject5-HT receptorsen
dc.subjectSerotoninen
dc.subjectMaternal behavioren
dc.subjectAggressionen
dc.titleEffect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000648266pt_BR
dc.type.originNacionalpt_BR


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