Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
dc.contributor.author | Veiga, Caroline Perinazzo da | pt_BR |
dc.contributor.author | Miczek, Klaus Alexander | pt_BR |
dc.contributor.author | Lucion, Aldo Bolten | pt_BR |
dc.contributor.author | Almeida, Rosa Maria Martins de | pt_BR |
dc.date.accessioned | 2010-04-24T04:15:48Z | pt_BR |
dc.date.issued | 2007 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21218 | pt_BR |
dc.description.abstract | Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 μg/0.2 μL, N = 8, and 1.0 μg/0.2 μL, N = 8) or CP-93,129 (1.0 μg/0.2 μL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was recorded for 10 min. The frequency and duration of aggressive and non-aggressive behaviors were analyzed using ANOVA and post hoc tests. CP-93,129 significantly decreased maternal aggression. The frequency of lateral attacks, bites and pinnings was reduced compared to control, while the non-aggressive behaviors and maternal care were largely unaffected by this treatment. CP-94,253 had no significant effects on aggressive or non-aggressive behaviors when microinjected into the same area of female rats. CP-93,129, a specific 5-HT1B receptor agonist, administered into the VO PFC reduced maternal aggressive behavior, while the CP-94,253 agonist did not significantly affect this behavior after social instigation in female rats. We conclude that only the 5-HT1B receptor agonist CP-93,129 administered into the VO PFC decreased aggression in female rats postpartum after social instigation. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 40, no. 6 (June 2007), p. 825-830 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Prefrontal cortex | en |
dc.subject | Serotonina : Comportamento : Agressividade : Ratas | pt_BR |
dc.subject | Receptores de serotonina | pt_BR |
dc.subject | 5-HT receptors | en |
dc.subject | Serotonin | en |
dc.subject | Maternal behavior | en |
dc.subject | Aggression | en |
dc.title | Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000648266 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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