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dc.contributor.authorGuimarães, Maria Fernanda Brandão de Resendept_BR
dc.contributor.authorRodrigues, Carlos Ewerton Maiapt_BR
dc.contributor.authorGomes, Kirla Wagner Potipt_BR
dc.contributor.authorMachado, Carla Jorgept_BR
dc.contributor.authorBrenol, Claiton Viegaspt_BR
dc.contributor.authorKrampe, Susana Ferreirapt_BR
dc.contributor.authorAndrade, Nicole Pamplona Bueno dept_BR
dc.contributor.authorKakehasi, Adriana Mariapt_BR
dc.date.accessioned2020-07-09T03:41:59Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn2523-3106pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/211614pt_BR
dc.description.abstractIntroduction: Rheumatoid arthritis (RA) is a well-documented independent risk factor for cardiovascular disease. Obesity may provide an additional link between inflammation and accelerated atherosclerosis in RA. Objective: To evaluate the association between obesity and disease parameters and cardiovascular risk factors in RA patients. Method: Cross-sectional study of a cohort of RA patients from three Brazilian teaching hospitals. Information on demographics, clinical parameters and the presence of cardiovascular risk factors was collected. Blood pressure, weight, height and waist circumference (WC) were measured during the first consultation. Laboratory data were retrieved from medical records. Obesity was defined according to the NCEP/ATPIII and IDF guidelines. The prevalence of obesity was determined cross-sectionally. Disease activity was evaluated using the DAS28 system (remission < 2.6; low 2.6–3.1; moderate 3.2–5.0; high > 5.1). Results: The sample consisted of 791 RA patients aged 54.7 ± 12.0 years, of whom 86.9% were women and 59.9% were Caucasian. The mean disease duration was 12.8 ± 8.9 years. Three quarters were rheumatoid factor-positive, the mean body mass index (BMI) was 27.1 ± 4.9, and the mean WC was 93.5 ± 12.5 cm. The observed risk factors included dyslipidemia (34.3%), type-2 diabetes (15%), hypertension (49.2%) and family history of premature cardiovascular disease (16.5%). BMIdefined obesity was highly prevalent (26.9%) and associated with age, hypertension and dyslipidemia. Increased WC was associated with diabetes, hypertension, dyslipidemia and disease activity. Conclusion: Obesity was highly prevalent in RA patients and associated with disease activity.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAdvances in rheumatology. [London]. Vol. 59 (2019), article 44. 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectObesidadept_BR
dc.subjectArtrite reumatóidept_BR
dc.subjectFatores de riscopt_BR
dc.subjectPrevalênciapt_BR
dc.subjectHipertensãopt_BR
dc.subjectDiabetes mellituspt_BR
dc.subjectDislipidemiaspt_BR
dc.titleHigh prevalence of obesity in rheumatoid arthritis patients : association with disease activity, hypertension, dyslipidemia and diabetes, a multi-center studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001114966pt_BR
dc.type.originEstrangeiropt_BR


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