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dc.contributor.authorSouza, Pablo Cambesespt_BR
dc.contributor.authorSantos, Emanuel Burck dospt_BR
dc.contributor.authorMotta, Guilherme Langpt_BR
dc.contributor.authorBona, Silvia Reginapt_BR
dc.contributor.authorSchaefer, Pedro Guilhermept_BR
dc.contributor.authorCampagnol, Danielapt_BR
dc.contributor.authorBortolini, Tiagopt_BR
dc.contributor.authorCorso, Carlos Otaviopt_BR
dc.date.accessioned2019-11-27T04:02:29Zpt_BR
dc.date.issued2018pt_BR
dc.identifier.issn0102-8650pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/202107pt_BR
dc.description.abstractPurpose: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. Methods: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, left nephrectomy was performed for histopathological evaluation, lipid peroxidation, and measurement of antioxidant enzyme activity. Serum was collected to measure urea and creatinine concentrations. Results: Histopathological damage induced by ischemia and reperfusion was more attenuated in the MEL+TH+IR group than in the MEL+IR and TH+IR groups (p<0.037). Superoxide dismutase activity was significantly higher (p<0.029) and creatinine (p<0.001) and urea (p<0.001) concentrations were significantly lower in the MEL+TH+IR group than in the MEL+IR and TH+IR groups. Conclusion: The combination of melatonin (MEL) and topical hypothermia (TH) better protects against renal I/R injury than does MEL or TH alone.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofActa cirúrgica brasileira. São Paulo. vol. 33, n. 3 (mar. 2018), p. 197-206pt_BR
dc.rightsOpen Accessen
dc.subjectMelatoninapt_BR
dc.subjectMelatoninen
dc.subjectHipotermiapt_BR
dc.subjectHypothermiaen
dc.subjectReperfusion injuryen
dc.subjectTraumatismo por reperfusãopt_BR
dc.subjectOxidative stressen
dc.subjectEstresse oxidativopt_BR
dc.subjectKidneyen
dc.subjectRimpt_BR
dc.subjectRatsen
dc.titleCombined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001105939pt_BR
dc.type.originNacionalpt_BR


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