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dc.contributor.authorCardinal, Tiago Madeirapt_BR
dc.contributor.authorAntunes, Luciana da Conceiçãopt_BR
dc.contributor.authorBrietzke, Aline Patríciapt_BR
dc.contributor.authorParizotti, Cristiane Schulzpt_BR
dc.contributor.authorCarvalho, Fabianapt_BR
dc.contributor.authorSouza, Andressa dept_BR
dc.contributor.authorTorres, Iraci Lucena da Silvapt_BR
dc.contributor.authorFregni, Felipept_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.date.accessioned2019-07-31T02:30:30Zpt_BR
dc.date.issued2019pt_BR
dc.identifier.issn1662-5161pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/197551pt_BR
dc.description.abstractBackground: Major depressive disorder (MDD) and fibromyalgia (FM) present overlapped symptoms. Although the connection between these two disorders has not been elucidated yet, the disruption of neuroplastic processes that mediate the equilibrium in the inhibitory systems stands out as a possible mechanism. Thus, the purpose of this cross-sectional exploratory study was: (i) to compare the motor cortex inhibition indexed by transcranial magnetic stimulation (TMS) measures [short intracortical inhibition (SICI) and intracortical facilitation (ICF)], as well as the function of descending pain modulatory systems (DPMS) among FM, MDD, and healthy subjects (HS); (ii) to compare SICI, ICF, and the role of DPMS evaluated by the change on Numerical Pain Scale (NPS) during the conditioned pain modulation test (CPMtest) between FM and MDD considering the BDNF-adjusted index; (iii) to assess the relationship between the role of DPMS and the BDNF-adjusted index, despite clinical diagnosis. Patients and Methods: A cohort of 63 women, aged 18 to 75 years [FM (n = 18), MDD (n = 19), and HC (n = 29)]. Results: The MANCOVA analysis revealed that the mean of SICI was 53.40% larger in FM compared to MDD [1.03 (0.50) vs. 0.55 (0.43)] and 66.99% larger compared to HC [1.03 (0.50) vs. 0.34 (0.19)], respectively. The inhibitory potency of the DPMS assessed by the change on the NPS during CPM-test was 112.29 % lower in the FM compared to MDD [0.22 (1.37) vs. 􀀀0.87 (1.49)]. The mean of BDNF from FM compared to MDD was 35.70% higher [49.82 (16.31) vs. 14.12 (8.86)]. In FM, the Spearman’s coefficient between the change in the NPS during CPM-test with the SICI was Rho = 􀀀0.49, [confidence interval (CI) 95%; 􀀀0.78 to 􀀀0.03]. The BDNF-adjusted index was positively correlated with the disinhibition of the DPMS. Conclusion: These findings support the hypothesis that in FM a deteriorated function of cortical inhibition, indexed by a higher SICI parameter, a lower function of the DPMS, together with a higher level of BDNF indicate that FM has different pathological substrates from depression. They suggest that an up-regulation phenomenon of intracortical inhibitory networks associated with a disruption of the DPMS function occurs in FM.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in Human Neuroscience. Lousanne. Vol. 13 (Apr. 2019), 138, 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFibromyalgiaen
dc.subjectTranstorno depressivo maiorpt_BR
dc.subjectDepressionen
dc.subjectFibromialgiapt_BR
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.subjectPrimary motor cortexen
dc.subjectPainen
dc.subjectCPMen
dc.subjectBDNFen
dc.titleDifferential neuroplastic changes in fibromyalgia and depression indexed by up-regulation of motor cortex inhibition and disinhibition of the descending pain system : an exploratory studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001093687pt_BR
dc.type.originEstrangeiropt_BR


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