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dc.contributor.authorSouza, Renato Teixeirapt_BR
dc.contributor.authorCecatti, Jose Guilhermept_BR
dc.contributor.authorNascimento, Maria Laura Costa dopt_BR
dc.contributor.authorNovais, Jussara de Souza Mayrinkpt_BR
dc.contributor.authorPacagnella, Rodolfo de Carvalhopt_BR
dc.contributor.authorPassini Júnior, Renatopt_BR
dc.contributor.authorFranchini, Kleber Gomespt_BR
dc.contributor.authorFeitosa, Francisco Edson de Lucenapt_BR
dc.contributor.authorCalderon, Iracema de Mattos Paranhospt_BR
dc.contributor.authorRocha Filho, Edilberto Alves Pereira dapt_BR
dc.contributor.authorLeite, Debora Farias Batistapt_BR
dc.contributor.authorVettorazzi, Janetept_BR
dc.contributor.authorKenny, Louise C.pt_BR
dc.contributor.authorBaker, Philip Newtonpt_BR
dc.date.accessioned2019-06-06T02:35:50Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn2314-6141pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/195598pt_BR
dc.description.abstractBackground. Our aim was to describe the steps in planning, implementing, and running a multicentre cohort study of maternal and perinatal health using a high-quality biobank comprised of maternal serum, plasma, and hair samples collected from five sites in Brazil.The Preterm SAMBA study, conducted by the Brazilian Network for Studies on Reproductive and Perinatal Health, was an innovative approach used to identify women at higher risk for preterm birth. It is also of great importance in the study of other maternal and perinatal complications in the context of Brazil, which is a middle-income country. Methods. We described phases of planning, implementing, and running the Preterm SAMBA study, a multicentre Brazilian cohort study of low-risk nulliparous pregnant women, to validate a set of metabolite biomarkers for preterm birth identified in an external cohort. Procedures and strategies used to plan, implement, and maintain this multicentre preterm birth study are described in detail. Barriers and experience cited in the current narrative are not usually discussed in the scientific literature or published study protocols. Results. Several barriers and strategies were identified in different phases of the Preterm SAMBA study at different levels of the study framework (steering committee; coordinating and local centres). Strategies implemented and resources used in the study are a legacy of the Brazilian Network, aimed at training collaborators in such complex settings. Conclusion. The Brazilian Network for Studies on Reproductive and Perinatal Health has gained some experience in conducting a multicentre cohort study using a resourceful biobank which may be helpful to other research groups and maternal/perinatal health networks that plan on employing a similar approach to a similar background.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBioMed research international. New York. vol. 2019, 5476350, 8 f.pt_BR
dc.rightsOpen Accessen
dc.subjectNascimento prematuropt_BR
dc.subjectAcademias e institutospt_BR
dc.titlePlanning, implementing, and running a multicentre preterm birth study with biobank resources in Brazil : the preterm SAMBA studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001093155pt_BR
dc.type.originEstrangeiropt_BR


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