• Effect of uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model 

      Castilhos, Lívia Gelain; Rezer, João Felipe Peres; Ruchel, Gerônimo; Thorstenberg, Maria Luiza Prates; Jaques, Jeandre Augusto dos Santos; Braun, Josiane Bizzi Schlemmer; Doleski, Pedro Henrique; Rossato, Mateus Fortes; Silva, Mariane Arnoldi da; Casali, Emerson Andre; Cruz, Ritiel Corrêa da; Ferreira, Juliano; Athayde, Margareth Linde; Gonçalves, Jamile Fabbrin; Leal, Daniela Bitencourt Rosa (2015) [Artigo de periódico]
      Background: Considering that adjuvant arthritis is an experimental model of arthritis widely used for preclinical testing of numerous anti-arthritic agents, which were taken by a large number of patients worldwide, it is ...
    • Metabolic fate of glutamine in lymphocytes, macrophages and neutrophils 

      Curi, Rui; Newsholme, Philip; Curi, Tania Cristina Pithon; Melo, Mariza Pires de; Garcia, C.; Bittencourt Junior, Paulo Ivo Homem de; Guimarães, A. R. P (1999) [Artigo de periódico]
      Eric Newsholme’s laboratory was the first to show glutamine utilization by lymphocytes and macrophages. Recently, we have found that neutrophils also utilize glutamine. This amino acid has been shown to play a role in ...
    • Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes : a prospective cohort study 

      Nedel, Wagner Luís; Carvalho, Afonso Kopczynski de; Rodolphi, Marcelo Salimen; Strogulski, Nathan Ryzewski; De Bastiani, Marco Antônio; Montes, Tiago Hermes Maeso; Abruzzi Junior, Jose; Galina, Antônio; Horvath, Tamas L.; Portela, Luis Valmor Cruz (2021) [Artigo de periódico]
      Background: Septic shock is a life-threatening condition that challenges immune cells to reprogram their mitochondrial metabolism towards to increase ATP synthesis for building an appropriate immunity. This could print ...