Navegação Artigos de Periódicos por Assunto "Guanosina"

Resultados 1-4 de 4

    • Antidepressant-like effects of chronic guanosine in the olfactory bulbectomy mouse model 

      Almeida, Roberto Farina de; Nonose, Yasmine; Ganzella, Marcelo; Loureiro, Samanta Oliveira; Rocha, Andréia Silva da; Machado, Daniele Guilhermano; Bellaver, Bruna; Fontella, Fernanda Urruth; Leffa, Douglas Teixeira; Pettenuzzo, Letícia Ferreira; Venturin, Gianina Teribele; Greggio, Samuel; Costa, Jaderson Costa da; Zimmer, Eduardo Rigon; Elisabetsky, Elaine; Souza, Diogo Onofre Gomes de (2021) [Artigo de periódico]
      Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants ...

    • Guanosine fast onset antidepressant-like effects in the olfactory bulbectomy mice model 

      Almeida, Roberto Farina de; Barbosa, Camila Pocharski; Rodrigues, Ana Lucia Severo; Elisabetsky, Elaine; Souza, Diogo Onofre Gomes de (2020) [Artigo de periódico]
      The treatment of major depressive disorder (MDD) is still a challenge. In the search for novel antidepressants, glutamatergic neuromodulators have been investigated as possible fast-acting antidepressants. Innovative studies ...

    • A new device for step-down inhibitory avoidance task : effects of low and high frequency in a novel device for passive inhibitory avoidance task that avoids bioimpedance variations 

      Borba Filho, Gilvan Luiz; Zenki, Kamila Cagliari; Kalinine, Eduardo; Baggio, Suelen; Pettenuzzo, Letícia Ferreira; Zimmer, Eduardo Rigon; Weis, Simone Nardin; Calcagnotto, Maria Elisa; Souza, Diogo Onofre Gomes de (2015) [Artigo de periódico]
      Background Step-down inhibitory avoidance task has been widely used to evaluate aversive memory, but crucial parameters inherent to traditional devices that may influence the behavior analysis (as stimulus frequency, ...

    • The potential therapeutic effect of guanosine after cortical focal ischemia in rats 

      Hansel, Gisele; Ramos, Denise Barbosa; Delgado, Camila Aguilar; Souza, Débora Guerini de; Almeida, Roberto Farina de; Portela, Luis Valmor Cruz; Quincozes-Santos, André; Souza, Diogo Onofre Gomes de (2014) [Artigo de periódico]
      Background and Purpose: Stroke is a devastating disease. Both excitotoxicity and oxidative stress play important roles in ischemic brain injury, along with harmful impacts on ischemic cerebral tissue. As guanosine plays ...