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dc.contributor.authorMardini, Victorpt_BR
dc.contributor.authorRohde, Luis Augusto Paimpt_BR
dc.contributor.authorCeresér, Keila Maria Mendespt_BR
dc.contributor.authorGubert, Carolina de Mourapt_BR
dc.contributor.authorSilva, Emily Galvão dapt_BR
dc.contributor.authorXavier , Fernando Antonio Costapt_BR
dc.contributor.authorParcianello, Rodrigo Ritterpt_BR
dc.contributor.authorRöhsig, Liane Marisept_BR
dc.contributor.authorPechansky, Flaviopt_BR
dc.contributor.authorSzobot, Claudia Macielpt_BR
dc.date.accessioned2018-09-05T02:28:52Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1516-4446pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/181616pt_BR
dc.description.abstractObjectives: To compare levels of a marker of lipid peroxidation (thiobarbituric acid reactive substances, TBARS) and brain-derived neurotrophic factor (BDNF) in umbilical cord blood (UCB) between newborns exposed to crack/cocaine in utero (exposed newborns [EN], n=57) and nonexposed newborns (NEN, n=99), as well as in maternal peripheral blood at delivery. Methods: This was a cross-sectional study. Potential confounders, including perinatal parameters, psychopathology, and use of other substances, were assessed. Results: After adjusting for potential confounders, adjusted mean BDNF was significantly higher in EN (3.86 ng/mL, 95% confidence interval [95%CI] 2.29-5.43) than in NEN (0.85 ng/mL, 95%CI 0.47-1.23; p o 0.001; Cohen effect size: 1.12), and significantly lower in crack/cocaine mothers than in control mothers (4.03 ng/mL, 95%CI 2.87-5.18 vs. 6.67 ng/mL, 95%CI 5.60-7.74; p = 0.006). The adjusted mean TBARS level was significantly lower in EN (63.97 mM MDA, 95%CI 39.43-88.50) than NEN (177.04 mM MDA, 95%CI 140.93-213.14; p o 0.001; effect size = 0.84), with no difference between mother groups (p = 0.86). Conclusions: The changes in TBARS levels observed in EN suggest that fetuses exposed to cocaine mobilize endogenous antioxidant routes since very early stages of development. The increase in BDNF levels in EN might indicate changes in fetal development, whereas the changes in BDNF levels in mothers provide evidence of the complex metabolic processes involved in drug use during pregnancy.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofRevista brasileira de psiquiatria (1999). São Paulo. Vol. 39, n. 3 (jul./set. 2017), p. 263-266pt_BR
dc.rightsOpen Accessen
dc.subjectFator neurotrófico derivado do encéfalopt_BR
dc.subjectTBARSen
dc.subjectCocaína crackpt_BR
dc.subjectBDNFen
dc.subjectTranstornos relacionados ao uso de cocaínapt_BR
dc.subjectPregnancyen
dc.subjectCrack/cocaineen
dc.subjectSangue fetalpt_BR
dc.subjectUmbilical cord blooden
dc.subjectGravidezpt_BR
dc.subjectNewbornen
dc.subjectSubstâncias reativas com ácido tiobarbitúricopt_BR
dc.titleTBARS and BDNF levels in newborns exposed to crack/cocaine during pregnancy : a comparative studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001074137pt_BR
dc.type.originNacionalpt_BR


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