Evaluation of systemic inflammation in patients being weaned from mechanical ventilation
dc.contributor.author | Forgiarini, Soraia Genebra Ibrahim | pt_BR |
dc.contributor.author | Rosa, Darlan Pase da | pt_BR |
dc.contributor.author | Forgiarini, Luiz Felipe | pt_BR |
dc.contributor.author | Teixeira, Cassiano | pt_BR |
dc.contributor.author | Andrade, Cristiano Feijó | pt_BR |
dc.contributor.author | Forgiarini Júnior, Luiz Alberto | pt_BR |
dc.contributor.author | Felix, Elaine Aparecida | pt_BR |
dc.contributor.author | Friedman, Gilberto | pt_BR |
dc.date.accessioned | 2018-07-04T02:26:32Z | pt_BR |
dc.date.issued | 2018 | pt_BR |
dc.identifier.issn | 1807-5932 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/180040 | pt_BR |
dc.description.abstract | OBJECTIVES: The aim of this study was to evaluate systemic inflammatory factors and their relation to success or failure in a spontaneous ventilation test. METHODS: This cross-sectional study included a sample of 54 adult patients. Demographic data and clinical parameters were collected, and blood samples were collected in the first minute of the spontaneous ventilation test to evaluate interleukin (IL)-1b, IL-6, IL-8, and IL-10, tumour necrosis factor alpha (TNFa) and C-reactive protein. RESULTS: Patients who experienced extubation failure presented a lower rapid shallow breathing index than those who passed, and these patients also showed a significant increase in C-reactive protein 48 hours after extubation. We observed, moreover, that each unit increase in inflammatory factors led to a higher risk of spontaneous ventilation test failure, with a risk of 2.27 (1.001 – 4.60, p=0.049) for TNFa, 2.23 (1.06 – 6.54, p=0.037) for IL-6, 2.66 (1.06 – 6.70, p=0.037) for IL-8 and 2.08 (1.01 – 4.31, p=0.04) for IL-10, and the rapid shallow breathing index was correlated with IL-1 (r=-0.51, p=0.04). CONCLUSIONS: C-reactive protein is increased in patients who fail the spontaneous ventilation test, and increased ILs are associated with a greater prevalence of failure in this process; the rapid shallow breathing index may not be effective in patients who present systemic inflammation. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Clinics. São Paulo. Vol. 73 (2018), e256 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Mechanical ventilation | en |
dc.subject | Respiração artificial | pt_BR |
dc.subject | Weaning | en |
dc.subject | Desmame do respirador | pt_BR |
dc.subject | Inflammatory factors | en |
dc.subject | Inflamação | pt_BR |
dc.subject | Fatores de risco | pt_BR |
dc.title | Evaluation of systemic inflammation in patients being weaned from mechanical ventilation | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001070329 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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