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dc.contributor.authorLima, Taiane Berguermaier dept_BR
dc.contributor.authorKlein, Isadora Perespt_BR
dc.contributor.authorOliveira, Márcia Gaiger dept_BR
dc.contributor.authorRados, Pantelis Varvakipt_BR
dc.contributor.authorSant'Ana Filho, Manoelpt_BR
dc.contributor.authorVisioli, Fernandapt_BR
dc.date.accessioned2018-05-25T11:11:41Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn0103-6440pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/178815pt_BR
dc.description.abstractThe aim of this study is to evaluate the immunohistochemical expression of E-cadherin, N-cadherin and Bmi-1, and their association with clinical parameters and with the degree of histopathological differentiation in oral squamous cell carcinomas. 65 squamous cell carcinoma samples were used for constructing a tissue microarray block, and then immunohistochemistry was performed for different markers. A semi-quantitative analysis of the amount of positive tumor cells was performed by two blind and calibrated observers (Kappa>0.75). The statistical Mann-Whitney and Kruskal-Wallis tests were used to evaluate the data. The correlation between variables was investigated by the Spearman test, and the significance level set at p<0.05. We observed higher expression of Bmi-1 in tumors located in the palate (p<0.0001). In addition, poorly differentiated tumors had a greater amount of Bmi-1 positive cells (p=0.0011). Regarding the other correlations between variables, no significant associations were detected. In conclusion, poorly differentiated squamous cell carcinomas located in the palate have higher immunostaining of Bmi-1, which can characterize activation of the Epithelial-Mesenchymal Transition process in these tumors.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian dental journal. Ribeirão Preto. Vol. 28, no. 5 (2017), p. 543-547pt_BR
dc.rightsOpen Accessen
dc.subjectOral canceren
dc.subjectPatologia bucalpt_BR
dc.subjectNeoplasias bucaispt_BR
dc.subjectPrognosisen
dc.subjectE-cadherinen
dc.subjectN-cadherinen
dc.subjectBmi-1en
dc.titleAnalysis of the epithelium-mesenchymal transition process on oral squamous cell carcinomaspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001068368pt_BR
dc.type.originNacionalpt_BR


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