The Central Sensitization Inventory validated and adapted for a brazilian population : psychometric properties and its relationship with brain-derived neurotrophic factor
dc.contributor.author | Caumo, Wolnei | pt_BR |
dc.contributor.author | Antunes, Luciana da Conceição | pt_BR |
dc.contributor.author | Elkfury, Jéssica Lorenzzi | pt_BR |
dc.contributor.author | Herbstrith, Evelyn Grabin | pt_BR |
dc.contributor.author | Sipmann, Raquel Busanello | pt_BR |
dc.contributor.author | Souza, Andressa de | pt_BR |
dc.contributor.author | Torres, Iraci Lucena da Silva | pt_BR |
dc.contributor.author | Santos, Vinícius Souza dos | pt_BR |
dc.contributor.author | Neblett, Randy | pt_BR |
dc.date.accessioned | 2018-02-20T02:26:12Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 1178-7090 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/172691 | pt_BR |
dc.description.abstract | Objectives: The primary aim was to assess the psychometric properties (including internal consistency, construct validity, reproducibility, and factor structure) of the Central Sensitization Inventory (CSI), adapted and validated for a Brazilian population (CSI-BP). Additionally, we evaluated the relationship between the CSI-BP and the serum brain-derived neurotrophic factor (BDNF) and determined if the symptoms elicited by the CSI-BP discriminate between subjects who do/do not respond to the conditioned pain modulation (CPM) task, as assessed by change in numeric pain scale (0–10) score. Patients and methods: A cross-sectional study was conducted in a pain clinic in a tertiary teaching hospital. A total of 222 adults with chronic musculoskeletal pain and 63 healthy control subjects completed the CSI-BP and the Brazilian Portuguese pain-catastrophizing scale (BPPCS). A team of experts translated the CSI according to the international guidelines. Test–retest, item analysis, convergent validity, and factor analysis were performed. Later, a random subsample (n=77) was used to correlate the CSI-BP adjusted index with change in numeric pain-scale score during the CPM task and a BDNF blood sample Results: The CSI-BP presented strong psychometric properties (test–retest reliability 0.91, Cronbach’s a=0.91). Confirmatory factor analysis yielded a four-factor structure, supporting the original English version. The CSI-BP adjusted index showed moderate positive correlation with the BP-PCS, and classified more than 80% of patients correctly vs healthy controls. Serum BDNF levels explained 27% of the variation in the CSI-BP adjusted index. Subjects with impairment in the descending modulatory system had higher CSI-BP adjusted index scores than subjects who responded normally to the CPM task: 49.35 (12.1) vs 39.5 (12.33), respectively (P<0.05). Conclusion: The CSI-BP was found to be a psychometrically strong and reliable instrument, with primary evidence of validity. Higher scores on the CSI-BP were correlated positively with serum BDNF and with greater dysfunction of the descending pain-modulatory system. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Journal of pain research [recurso eletrônico]. Auckland. Vol. 2017, no. 10 (1 Sept. 2017), p. 2109-2122 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Confirmatory factor analysis | en |
dc.subject | Psicometria | pt_BR |
dc.subject | Fator neurotrófico derivado do encéfalo | pt_BR |
dc.subject | Cross-cultural adaptation | en |
dc.subject | Conditioned pain modulation | en |
dc.subject | Análise fatorial | pt_BR |
dc.subject | Sensibilização do sistema nervoso central | pt_BR |
dc.subject | Serum brain-derived neurotrophic factor | en |
dc.subject | Central sensitization | en |
dc.subject | Dor crônica | pt_BR |
dc.subject | Chronic pain | en |
dc.title | The Central Sensitization Inventory validated and adapted for a brazilian population : psychometric properties and its relationship with brain-derived neurotrophic factor | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001059387 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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