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dc.contributor.authorNascimento, Thiago Mazzupt_BR
dc.contributor.authorMelo, Débora Gusmãopt_BR
dc.contributor.authorMorbioli, Giorgio Gianinipt_BR
dc.contributor.authorCarrilho, Emanuelpt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorSilva, André Anjos dapt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.date.accessioned2017-12-05T02:22:28Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/170841pt_BR
dc.description.abstractCongenital anomalies are already the second cause of infant mortality in Brazil, as in many other middle-income countries in Latin America. Birth defects are a result of both genetic and environmental factors, but a multifactorial etiology has been more frequently observed. Here, we address the environmental causes of birth defects – or teratogens – as a public health issue and present their mechanisms of action, categories and their respective maternal- fetal deleterious effects. We also present a survey from 2008 to 2013 of Brazilian cases involving congenital anomalies (annual average of 20,205), fetal deaths (annual average of 1,530), infant hospitalizations (annual average of 82,452), number of deaths of hospitalized infants (annual average of 2,175), and the average cost of hospitalizations (annual cost of $7,758). Moreover, we report on Brazilian cases of teratogenesis due to the recent Zika virus infection, and to the use of misoprostol, thalidomide, alcohol and illicit drugs. Special attention has been given to the Zika virus infection, now proven to be responsible for the microcephaly outbreak in Brazil, with 8,039 cases under investigation (from October 2015 to June 2016). From those cases, 1,616 were confirmed and 324 deaths occurred due to microcephaly complications or alterations on the central nervous system. Congenital anomalies impact life quality and raise costs in specialized care, justifying the classification of teratogens as a public health issue.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 40, no. 2, (Apr./Jun. 2017), p. 387-397pt_BR
dc.rightsOpen Accessen
dc.subjectTeratogênesept_BR
dc.subjectBirth defectsen
dc.subjectTeratogensen
dc.subjectInfecção pelo Zika viruspt_BR
dc.subjectZika virusen
dc.subjectSaúde públicapt_BR
dc.subjectGravidezpt_BR
dc.subjectPregnancyen
dc.subjectPublic healthen
dc.subjectMalformacoes congenitas : Criancaspt_BR
dc.titleTeratogens : a public health issue - a brazilian overviewpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001047233pt_BR
dc.type.originNacionalpt_BR


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